PMID- 29034762
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20190215
IS  - 1476-4954 (Electronic)
IS  - 1476-4954 (Linking)
VI  - 32
IP  - 1
DP  - 2019 Jan
TI  - Exploring the cause of early miscarriage with SNP-array analysis and karyotyping.
PG  - 1-10
LID - 10.1080/14767058.2017.1367379 [doi]
AB  - OBJECTIVE: The aim of this study is to explore the cause of miscarriage, 
      providing risk assessment to guide the next pregnancy. METHODS: Four hundred 
      eighty-four products-of-conception (POC) samples were analyzed by single 
      nucleotide polymorphism (SNP) array, and peripheral blood samples of couples were 
      collected for karyotyping or fluorescence in situ hybridization (FISH) analysis. 
      RESULTS: Four hundred sixty-eight of the 484 (96.7%) fresh POC samples were 
      successfully analyzed using SNP-array. The rate of clinically significant 
      chromosomal abnormalities were 58.3% (274/468), in which rates of aneuploidy, 
      polyploidy, partial aneuploidy, uniparental isodisomy (isoUPD), and pathogenic 
      microdeletion/microduplication were 43.4% (203/468), 8.8% (41/468), 3.6% 
      (17/468), 1.9% (9/48), and 0.9% (4/468), respectively. The percentage of 
      embryonic chromosomal abnormalities significantly increased with maternal age of 
      patients older than 35 years old. Among 468 couples, 12 major chromosomal 
      rearrangements were detected by G-banding, including nine reciprocal 
      translocations, two Robertsonian translocations, and one superfemale. 
      CONCLUSIONS: Chromosome abnormality is the main causes of early miscarriage, and 
      aneuploidies are the most common type of chromosomal abnormalities. Application 
      of SNP array and karyotyping in early miscarriage can provide more genetic 
      information about miscarriage, providing risk assessment to guide the next 
      pregnancy.
FAU - Qu, Suzhen
AU  - Qu S
AD  - a Center for Genetics and Prenatal Diagnosis , the First Affiliated Hospital of 
      Zhengzhou University , Zhengzhou , Henan , China.
FAU - Wang, Li
AU  - Wang L
AD  - a Center for Genetics and Prenatal Diagnosis , the First Affiliated Hospital of 
      Zhengzhou University , Zhengzhou , Henan , China.
FAU - Cai, Aojie
AU  - Cai A
AD  - a Center for Genetics and Prenatal Diagnosis , the First Affiliated Hospital of 
      Zhengzhou University , Zhengzhou , Henan , China.
FAU - Cui, Siying
AU  - Cui S
AD  - a Center for Genetics and Prenatal Diagnosis , the First Affiliated Hospital of 
      Zhengzhou University , Zhengzhou , Henan , China.
FAU - Bai, Nan
AU  - Bai N
AD  - a Center for Genetics and Prenatal Diagnosis , the First Affiliated Hospital of 
      Zhengzhou University , Zhengzhou , Henan , China.
FAU - Liu, Ning
AU  - Liu N
AD  - a Center for Genetics and Prenatal Diagnosis , the First Affiliated Hospital of 
      Zhengzhou University , Zhengzhou , Henan , China.
FAU - Kong, Xiangdong
AU  - Kong X
AD  - a Center for Genetics and Prenatal Diagnosis , the First Affiliated Hospital of 
      Zhengzhou University , Zhengzhou , Henan , China.
LA  - eng
PT  - Journal Article
DEP - 20171016
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Abortion, Spontaneous/*genetics
MH  - Adult
MH  - Chromosome Aberrations/*statistics & numerical data
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Karyotyping
MH  - Maternal Age
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Young Adult
OTO - NOTNLM
OT  - Aneuploidy
OT  - SNP-array
OT  - chromosome abnormality
OT  - early miscarriage
OT  - karyotyping
OT  - products of conception
EDAT- 2017/10/17 06:00
MHDA- 2019/02/08 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - 10.1080/14767058.2017.1367379 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2019 Jan;32(1):1-10. doi: 
      10.1080/14767058.2017.1367379. Epub 2017 Oct 16.