PMID- 29035111
OWN - NLM
STAT- MEDLINE
DCOM- 20180529
LR  - 20180529
IS  - 1876-2891 (Electronic)
IS  - 1876-2883 (Linking)
VI  - 8
IP  - 5
DP  - 2017 Oct 13
TI  - Identification of atopic dermatitis phenotypes with good responses to probiotics 
      (Lactobacillus plantarum CJLP133) in children.
PG  - 755-761
LID - 10.3920/BM2017.0034 [doi]
AB  - The therapeutic effect of probiotics in atopic dermatitis (AD) remains 
      controversial and varies according to the individual patient. We aimed to 
      identify a population of AD patients with a good clinical response to probiotic 
      treatment. We recruited 76 children with a median age of 7.1 years who suffered 
      from moderate to severe AD. After a 2-week washout period, all patients were 
      given Lactobacillus plantarum CJLP133 at a dosage of 1x10(10) colony-forming 
      units once a day for 12 weeks. We measured eosinophil counts in the peripheral 
      blood, the proportion of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) cells in 
      CD4(+) T cells, serum total immunoglobulin E (IgE) levels, and specific IgE 
      against common allergens before the start of the treatment (T1) and at 
      discontinuation (T2). Responders were defined as patients with at least a 30% 
      reduction in the SCORing of AD (SCORAD) index after treatment. There were 36 
      responders and 40 non-responders after probiotic treatment. The median SCORAD was 
      reduced from 29.5 (range 20.6-46.3) at T1 to 16.4 (range 6.3-30.8) at T2 in the 
      responder group (P<0.001). In multivariable logistic regression analysis, a good 
      clinical response was significantly associated with high total IgE levels (aOR 
      5.1, 95% CI 1.1-23.6), increased expression of transforming growth factor (TGF)-beta 
      (aOR 4.6, 95% CI 1.3-15.9), and a high proportion of Treg cells in CD4(+) T cells 
      (aOR 3.7, 95% CI 1.1-12.7) at T1. In the responder group, the proportion of Treg 
      cells was significantly increased after 12 weeks of treatment (P=0.004), while 
      TGF-beta mRNA expression was decreased (P=0.017). Our results suggest that a 
      subgroup of patients with a specific AD phenotype showing an immunologically 
      active state (high total IgE, increased expression of TGF-beta, high numbers of Treg 
      cells) may benefit from probiotic treatment with L. plantarum CJLP133.
FAU - Kim, J
AU  - Kim J
AD  - 1 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, 81 Irwon-ro, Gangnamgu, Seoul 06351, Republic of Korea.
AD  - 2 Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, 
      Republic of Korea.
FAU - Lee, B S
AU  - Lee BS
AD  - 2 Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, 
      Republic of Korea.
FAU - Kim, B
AU  - Kim B
AD  - 3 Beneficial Microbes R&D Center, CJ CheilJedang Corporation, Suwon, Republic of 
      Korea.
FAU - Na, I
AU  - Na I
AD  - 2 Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, 
      Republic of Korea.
FAU - Lee, J
AU  - Lee J
AD  - 2 Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, 
      Republic of Korea.
FAU - Lee, J Y
AU  - Lee JY
AD  - 1 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, 81 Irwon-ro, Gangnamgu, Seoul 06351, Republic of Korea.
AD  - 2 Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, 
      Republic of Korea.
FAU - Park, M R
AU  - Park MR
AD  - 4 Department of Pediatrics, Sung-Ae Hospital, Seoul, Republic of Korea.
FAU - Kim, H
AU  - Kim H
AD  - 5 Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, 
      Republic of Korea.
FAU - Sohn, I
AU  - Sohn I
AD  - 5 Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, 
      Republic of Korea.
FAU - Ahn, K
AU  - Ahn K
AD  - 1 Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, 81 Irwon-ro, Gangnamgu, Seoul 06351, Republic of Korea.
AD  - 2 Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Benef Microbes
JT  - Beneficial microbes
JID - 101507616
RN  - 0 (Biomarkers)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adolescent
MH  - Biomarkers/blood
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*pathology/*therapy
MH  - Female
MH  - Humans
MH  - Immunologic Factors/*administration & dosage
MH  - Infant
MH  - Lactobacillus plantarum/*growth & development
MH  - Male
MH  - Probiotics/*administration & dosage
MH  - Severity of Illness Index
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Lactobacillus plantarum
OT  - atopic dermatitis
OT  - probiotics
OT  - regulatory T cells
OT  - response
EDAT- 2017/10/17 06:00
MHDA- 2018/05/31 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [entrez]
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/05/31 06:00 [medline]
AID - 10.3920/BM2017.0034 [doi]
PST - ppublish
SO  - Benef Microbes. 2017 Oct 13;8(5):755-761. doi: 10.3920/BM2017.0034.