PMID- 29035604
OWN - NLM
STAT- MEDLINE
DCOM- 20190903
LR  - 20190903
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 55
IP  - 10
DP  - 2018 Oct
TI  - Biomarkers for differentiation of patients with asthma and chronic obstructive 
      pulmonary disease.
PG  - 1052-1058
LID - 10.1080/02770903.2017.1391281 [doi]
AB  - OBJECTIVE: Asthma and chronic obstructive pulmonary disease (COPD) are airflow 
      limitation diseases with similar clinical manifestations but different 
      pathophysiologic mechanisms. To implement the appropriate treatment, it is 
      important to distinguish between asthma and COPD which sometimes might result 
      difficult in clinical practice. We evaluated biomarkers to distinguish between 
      asthma and COPD. METHODS: Blood eosinophil counts and fractional exhaled nitric 
      oxide (FeNO) levels were analyzed. Serum periostin, interleukin-25 (IL-25), and 
      immunoglobulin E (IgE) concentrations were compared between patients with asthma 
      (n = 60), including atopic-asthma (n = 30) and non-atopic asthma (n = 30), and 
      patients with COPD (n = 30). RESULTS: Significantly higher peripheral blood 
      eosinophil counts (p < 0.001), FeNO levels (p < 0.001), and total serum IgE (P = 
      0.003) concentrations, but not serum periostin (p = 0.584) or serum IL-25 (p = 
      0.085) concentrations, were detected in patients with asthma compared to patients 
      with COPD. Serum periostin and IgE concentrations were increased in patients with 
      atopic-asthma compared with those with non-atopic asthma and COPD (p < 0.05). The 
      FeNO levels were significantly correlated with the peripheral blood eosinophil 
      counts (r = 0.430, p = 0.001) and serum IL-25 concentrations (r = 0.338, p = 
      0.009) in patients with asthma. The serum periostin concentrations were also 
      correlated with the serum IgE concentrations (r = 0.375, p = 0.003)and FeNO 
      levels (r = 0.291, p = 0.024) in patients with asthma. Asthma patients were 
      effectively differentiated from COPD patients based on the FeNO levels (p < 
      0.001) and peripheral blood eosinophil counts (p < 0.001). CONCLUSIONS: FeNO 
      levels and peripheral blood eosinophil counts were useful biomarkers for 
      distinguishing between patients with asthma and COPD. Serum periostin and IgE 
      concentrations could be biomarkers for atopic asthma.
FAU - Katoh, Shigeki
AU  - Katoh S
AD  - a Department of Respiratory Medicine , Kawasaki Medical School , Kurashiki , 
      Okayama , Japan.
FAU - Ikeda, Masaki
AU  - Ikeda M
AD  - a Department of Respiratory Medicine , Kawasaki Medical School , Kurashiki , 
      Okayama , Japan.
FAU - Shirai, Ryo
AU  - Shirai R
AD  - a Department of Respiratory Medicine , Kawasaki Medical School , Kurashiki , 
      Okayama , Japan.
FAU - Abe, Masaaki
AU  - Abe M
AD  - a Department of Respiratory Medicine , Kawasaki Medical School , Kurashiki , 
      Okayama , Japan.
FAU - Ohue, Yoshihiro
AU  - Ohue Y
AD  - a Department of Respiratory Medicine , Kawasaki Medical School , Kurashiki , 
      Okayama , Japan.
FAU - Kobashi, Yoshihiro
AU  - Kobashi Y
AD  - a Department of Respiratory Medicine , Kawasaki Medical School , Kurashiki , 
      Okayama , Japan.
FAU - Oka, Mikio
AU  - Oka M
AD  - a Department of Respiratory Medicine , Kawasaki Medical School , Kurashiki , 
      Okayama , Japan.
LA  - eng
PT  - Journal Article
DEP - 20171201
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Interleukin-17)
RN  - 0 (POSTN protein, human)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Asthma/*blood/*diagnosis/epidemiology
MH  - Biomarkers
MH  - Cell Adhesion Molecules/blood
MH  - Diagnosis, Differential
MH  - Eosinophils/metabolism
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/blood/epidemiology
MH  - Immunoglobulin E/blood
MH  - Interleukin-17/blood
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/analysis
MH  - Pulmonary Disease, Chronic Obstructive/*blood/*diagnosis/epidemiology
MH  - Respiratory Function Tests
MH  - Smoking/epidemiology
OTO - NOTNLM
OT  - Eosinophil
OT  - fractional exhaled nitric oxide
OT  - immunoglobulin E
OT  - interleukin-25
OT  - periostin
EDAT- 2017/10/17 06:00
MHDA- 2019/09/04 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2019/09/04 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - 10.1080/02770903.2017.1391281 [doi]
PST - ppublish
SO  - J Asthma. 2018 Oct;55(10):1052-1058. doi: 10.1080/02770903.2017.1391281. Epub 
      2017 Dec 1.