PMID- 29035920
OWN - NLM
STAT- MEDLINE
DCOM- 20190529
LR  - 20190529
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 29
IP  - 4
DP  - 2018 Jun
TI  - The antidepressant-like effects of sinomenine in mice: a behavioral and 
      neurobiological characterization.
PG  - 306-315
LID - 10.1097/FBP.0000000000000350 [doi]
AB  - Sinomenine is a bioactive alkaloid extracted from Sinomenium acutum. Here, we 
      investigated the antidepressant effects of sinomenine in mice. The antidepressant 
      actions of sinomenine were first examined in the forced-swim test and the 
      tail-suspension test, and then assessed in the chronic social defeat stress 
      (CSDS) model of depression. Changes in the brain-derived neurotrophic factor 
      (BDNF) signaling pathway after CSDS and sinomenine treatment were also 
      investigated. A tryptophan hydroxylase inhibitor and a BDNF signaling inhibitor 
      were also used to determine the pharmacological mechanisms of sinomenine. It was 
      found that sinomenine induced antidepressant-like effects in the forced-swim test 
      and tail-suspension test without affecting the locomotor activity of mice. 
      Sinomenine also prevented the CSDS-induced depressive-like symptoms. Moreover, 
      sinomenine fully restored the CSDS-induced decrease in the hippocampal BDNF 
      signaling pathway, whereas a BDNF signaling inhibitor, but not a tryptophan 
      hydroxylase inhibitor, blocked the antidepressant effects of sinomenine. In 
      conclusion, sinomenine exerts antidepressant effects in mice by promoting the 
      hippocampal BDNF signaling pathway.
FAU - Li, Xiuqin
AU  - Li X
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Medical School of Nantong University.
FAU - Liu, Chao
AU  - Liu C
AD  - Yangtze River Pharmaceutical Group, Taizhou.
FAU - Jiang, Bo
AU  - Jiang B
AD  - Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 
      Jiangsu Province, China.
FAU - Chen, Kai
AU  - Chen K
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Medical School of Nantong University.
FAU - Li, Wenjuan
AU  - Li W
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Medical School of Nantong University.
FAU - Wang, Hongze
AU  - Wang H
AD  - Department of Pharmacy, Taizhou People's Hospital, The Fifth Affiliated Hospital 
      of Medical School of Nantong University.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Morphinans)
RN  - 333DO1RDJY (Serotonin)
RN  - 63LT81K70N (sinomenine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*drug therapy
MH  - Depressive Disorder/drug therapy
MH  - Disease Models, Animal
MH  - Hippocampus/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Morphinans/metabolism/*pharmacology
MH  - Neurogenesis/drug effects
MH  - Serotonin/metabolism
MH  - Signal Transduction/drug effects
MH  - Stress, Psychological/drug therapy
EDAT- 2017/10/17 06:00
MHDA- 2019/05/30 06:00
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2019/05/30 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
AID - 10.1097/FBP.0000000000000350 [doi]
PST - ppublish
SO  - Behav Pharmacol. 2018 Jun;29(4):306-315. doi: 10.1097/FBP.0000000000000350.