PMID- 29036587
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20190216
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 44
IP  - 2
DP  - 2018 Feb 15
TI  - Latent Profile Analysis and Conversion to Psychosis: Characterizing Subgroups to 
      Enhance Risk Prediction.
PG  - 286-296
LID - 10.1093/schbul/sbx080 [doi]
AB  - BACKGROUND: Groups at clinical high risk (CHR) of developing psychosis are 
      heterogeneous, composed of individuals with different clusters of symptoms. It is 
      likely that there exist subgroups, each associated with different symptom 
      constellations and probabilities of conversion. METHOD: Present study used latent 
      profile analysis (LPA) to ascertain subgroups in a combined sample of CHR (n = 
      171) and help-seeking controls (HSCs; n = 100; PREDICT study). Indicators in the 
      LPA model included baseline Scale of Prodromal Symptoms (SOPS), Calgary 
      Depression Scale for Schizophrenia (CDSS), and neurocognitive performance as 
      measured by multiple instruments, including category instances (CAT). Subgroups 
      were further characterized using covariates measuring demographic and clinical 
      features. RESULTS: Three classes emerged: class 1 (mild, transition rate 5.6%), 
      lowest SOPS and depression scores, intact neurocognitive performance; class 2 
      (paranoid-affective, transition rate 14.2%), highest suspiciousness, mild 
      negative symptoms, moderate depression; and class 3 (negative-neurocognitive, 
      transition rate 29.3%), highest negative symptoms, neurocognitive impairment, 
      social cognitive impairment. Classes 2 and 3 evidenced poor social functioning. 
      CONCLUSIONS: Results support a subgroup approach to research, assessment, and 
      treatment of help-seeking individuals. Class 3 may be an early risk stage of 
      developing schizophrenia.
FAU - Healey, Kristin M
AU  - Healey KM
AD  - Department of Psychology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC.
FAU - Penn, David L
AU  - Penn DL
AD  - Department of Psychology, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC.
AD  - School of Psychology, Australian Catholic University, Melbourne, Australia.
FAU - Perkins, Diana
AU  - Perkins D
AD  - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT.
FAU - Keefe, Richard S E
AU  - Keefe RSE
AD  - Department of Psychiatry, Duke University Medical Center, Durham, NC.
FAU - Addington, Jean
AU  - Addington J
AD  - Department of Psychiatry, Faculty of Medicine, University of Calgary, Calgary, 
      AB, Canada.
LA  - eng
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - U01 MH066134/MH/NIMH NIH HHS/United States
GR  - U01 MH066069/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cognitive Dysfunction/*classification/epidemiology/etiology/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Prodromal Symptoms
MH  - Psychiatric Status Rating Scales/*statistics & numerical data
MH  - Psychotic Disorders/*classification/complications/epidemiology/physiopathology
MH  - Risk Assessment/*statistics & numerical data
MH  - Schizophrenia/*classification/complications/epidemiology/physiopathology
MH  - Young Adult
PMC - PMC5815120
EDAT- 2017/10/17 06:00
MHDA- 2018/11/15 06:00
PMCR- 2019/02/15
CRDT- 2017/10/17 06:00
PHST- 2017/10/17 06:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
PHST- 2017/10/17 06:00 [entrez]
PHST- 2019/02/15 00:00 [pmc-release]
AID - 3964615 [pii]
AID - sbx080 [pii]
AID - 10.1093/schbul/sbx080 [doi]
PST - ppublish
SO  - Schizophr Bull. 2018 Feb 15;44(2):286-296. doi: 10.1093/schbul/sbx080.