PMID- 29036805
OWN - NLM
STAT- MEDLINE
DCOM- 20180820
LR  - 20180820
IS  - 1875-869X (Electronic)
IS  - 1093-2607 (Linking)
VI  - 26
IP  - 2
DP  - 2018 Feb 5
TI  - Determining the IgM and IgG antibodies titer against HSV1, HSV2 and CMV in the 
      serum of schizophrenia patients.
PG  - 87-93
LID - 10.3233/HAB-170325 [doi]
AB  - Schizophrenia is a destructive clinical syndrome with diverse mental pathologies. 
      Different mechanisms and factors have a role in this disease. A possible 
      mechanism is that teratogenic viruses cause brain changes and results in the 
      disease appearance. The schizophrenia patients were diagnosed by psychologists 
      and with the consent of patients, five CC of venous blood was drawn. Than Serum 
      samples were isolated and immunoglobulin M (IgM) and immunoglobulin G (IgG) 
      antibodies against herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2) 
      and cytomegalovirus (CMV) were quantified by ELISA sandwich kit. The Results 
      showed that anti-CMV and anti-HSV1 and anti-HSV2 IgG antibodies in schizophrenia 
      patients were increased significantly (p< 0.05). The increasing of the anti-HSV2 
      IgM was also observed but increasing amount of the anti-HSV1 IgM was not 
      statistically significant (p< 0.05). Therefore, as a result of this study CMV and 
      HSV1 and HSV2 infection can probably intensify the symptoms in schizophrenia 
      patients.
FAU - Mohagheghi, Masome
AU  - Mohagheghi M
AD  - Islamic Azad University, Hamadan Branch, Hamadan, Iran.
FAU - Eftekharian, Mohammad Mahdi
AU  - Eftekharian MM
AD  - Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
AD  - Faculty of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran.
AD  - Research Center for Molecular Medicine, Hamadan University of Medical Sciences, 
      Hamadan, Iran.
FAU - Taheri, Mohammad
AU  - Taheri M
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
AD  - Urogenital Stem Cell Research, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Alikhani, Mohammad Yousef
AU  - Alikhani MY
AD  - Department of Microbiology, Hamadan University of Medical Sciences, Hamadan, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Hum Antibodies
JT  - Human antibodies
JID - 9711270
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*blood
MH  - Case-Control Studies
MH  - Cytomegalovirus/immunology/pathogenicity
MH  - Cytomegalovirus Infections/blood/*complications/immunology/virology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Herpes Genitalis/blood/*complications/immunology/virology
MH  - Herpes Simplex/blood/*complications/immunology/virology
MH  - Herpesvirus 1, Human/immunology/pathogenicity
MH  - Herpesvirus 2, Human/immunology/pathogenicity
MH  - Humans
MH  - Immunoglobulin G/*blood
MH  - Immunoglobulin M/*blood
MH  - Male
MH  - Middle Aged
MH  - Schizophrenia/blood/*complications/immunology/virology
OTO - NOTNLM
OT  - Schizophrenia
OT  - cytomegalovirus
OT  - herpes simplex virus 1
OT  - herpes simplex virus 2
EDAT- 2017/10/19 06:00
MHDA- 2018/08/21 06:00
CRDT- 2017/10/18 06:00
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/08/21 06:00 [medline]
PHST- 2017/10/18 06:00 [entrez]
AID - HAB325 [pii]
AID - 10.3233/HAB-170325 [doi]
PST - ppublish
SO  - Hum Antibodies. 2018 Feb 5;26(2):87-93. doi: 10.3233/HAB-170325.