PMID- 29038669
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1918-3003 (Print)
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Linking)
VI  - 9
IP  - 11
DP  - 2017 Nov
TI  - Body Composition Is Altered in Pre-Diabetic Patients With Impaired Fasting 
      Glucose Tolerance: Results From the NHANES Survey.
PG  - 917-925
LID - 10.14740/jocmr3142w [doi]
AB  - BACKGROUND: Previous studies suggest that type 2 diabetes mellitus (T2DM) is 
      associated with a loss of muscle mass but the impact of fasting blood glucose 
      (FBG) on body composition remains underappreciated in pre-diabetic subjects. The 
      aim of this study was to determine the influence of FBG on lean mass (LM), fat 
      mass (FM) and their distribution (trunk vs. appendicular), separately in 
      middle-aged men and women. METHODS: One thousand nine hundred and eleven (1,911) 
      men (63.9 +/- 11.7 years) and 1,977 women (63.7 +/- 12.1 years) from the National 
      Health and Nutrition Examination Survey (1999 - 2004) were divided into four 
      groups: normal glucose tolerance (NGT), low impaired fasting glucose (IFG), high 
      IFG and T2DM. Body composition was obtained from dual X-ray absorptiometry (DXA). 
      RESULTS: Of the patients, 68.7% had NGT, 16.1% low IFG, 9.4% high IFG and 5.8% 
      T2DM. After adjustment for age, body mass index, ethnicity, smoking, alcohol and 
      physical activity (PA), no change in appendicular LM was observed between groups, 
      but significant increases in trunk FM (in both gender) and trunk LM (in women) 
      were found with increased glucose intolerance (T2DM > IFG > NGT), as well as 
      significant decreases in trunk and total LM/FM ratios (T2DM < IFG < NGT) and a 
      significant increase in trunk/appendicular FM ratio (T2DM > IFG > NGT). 
      CONCLUSIONS: Elevated FBG within the normal range is not associated with a 
      significant loss of appendicular LM, but modifications in LM and FM trunk and 
      total distribution with IFG suggest that nutritional and physical lifestyle 
      strategies should be implemented in the pre-diabetic state.
FAU - Julian, Valerie
AU  - Julian V
AD  - Service Medecine du Sport et Explorations Fonctionnelles, CHU Clermont-Ferrand, 
      INRA, Universite Clermont Auvergne, Clermont-Ferrand, France.
AD  - Unite de Nutrition Humaine, CHU Clermont-Ferrand, INRA, Universite Clermont 
      Auvergne, Clermont-Ferrand, France.
FAU - Blondel, Romain
AU  - Blondel R
AD  - Service Medecine du Sport et Explorations Fonctionnelles, CHU Clermont-Ferrand, 
      INRA, Universite Clermont Auvergne, Clermont-Ferrand, France.
FAU - Pereira, Bruno
AU  - Pereira B
AD  - Service de Biostatistique, CHU Clermont-Ferrand, Universite Clermont Auvergne, 
      Clermont-Ferrand, France.
FAU - Thivel, David
AU  - Thivel D
AD  - Laboratoire AME2P, Universite Clermont Auvergne, Aubiere, France.
FAU - Boirie, Yves
AU  - Boirie Y
AD  - Unite de Nutrition Humaine, CHU Clermont-Ferrand, INRA, Universite Clermont 
      Auvergne, Clermont-Ferrand, France.
AD  - Service de Nutrition Clinique CHU Clermont-Ferrand, INRA, Universite Clermont 
      Auvergne, Clermont-Ferrand, France.
FAU - Duclos, Martine
AU  - Duclos M
AD  - Service Medecine du Sport et Explorations Fonctionnelles, CHU Clermont-Ferrand, 
      INRA, Universite Clermont Auvergne, Clermont-Ferrand, France.
AD  - Unite de Nutrition Humaine, CHU Clermont-Ferrand, INRA, Universite Clermont 
      Auvergne, Clermont-Ferrand, France.
LA  - eng
PT  - Journal Article
DEP - 20171002
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC5633092
OTO - NOTNLM
OT  - Body composition
OT  - Gender
OT  - Insulin resistance
OT  - Mobility
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2017/10/19 06:00
MHDA- 2017/10/19 06:01
PMCR- 2017/10/02
CRDT- 2017/10/18 06:00
PHST- 2017/07/29 00:00 [received]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/10/18 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/10/19 06:01 [medline]
PHST- 2017/10/02 00:00 [pmc-release]
AID - 10.14740/jocmr3142w [doi]
PST - ppublish
SO  - J Clin Med Res. 2017 Nov;9(11):917-925. doi: 10.14740/jocmr3142w. Epub 2017 Oct 
      2.