PMID- 29039974
OWN - NLM
STAT- MEDLINE
DCOM- 20180717
LR  - 20180717
IS  - 1525-6065 (Electronic)
IS  - 1064-1955 (Linking)
VI  - 36
IP  - 4
DP  - 2017 Nov
TI  - Role of kidney biomarkers [Kidney injury molecule-1, Calbindin, Interleukin-18 
      and Monocyte chemoattractant protein-1] in HIV associated pre-eclampsia.
PG  - 288-294
LID - 10.1080/10641955.2017.1385793 [doi]
AB  - OBJECTIVE: Both HIV infection and pre-eclampsia (PE) are associated with 
      considerable maternal mortality in South Africa. This study was designed to 
      compare the urinary levels of kidney injury molecule-1 (KIM-1), calbindin, 
      interleukin-18 (IL-18), and monocyte chemoattractant protein-1 (MCP-1) in HIV 
      associated normotensive and preeclamptic pregnancies. METHODS: Following ethical 
      approval and written consent, urine samples were collected from HIV negative (HIV 
      -ve) normotensive pregnant (n = 19), HIV positive (HIV +ve) normotensive pregnant 
      (n = 19), HIV -ve pre-eclamptic (n = 19) and HIV +ve pre-eclamptic (n = 19) 
      women. The concentrations of KIM-1, calbindin, IL-18 and MCP-1 were assessed 
      using the Bioplex technology. RESULTS: In contrast to IL-18 (p > 0.05) and MCP-1 
      (p > 0.05), the concentrations of KIM-1 (p = 0.02) and calbindin (p = 0.02) were 
      significantly higher in PE compared to normotensive pregnancies, irrespective of 
      HIV status. Based on HIV status, all 4 analytes were similar between HIV+ve and 
      HIV-ve groups. Urinary KIM-1 levels in the HIV -ve pre-eclamptics were 
      significantly higher than those in the HIV -ve women with normal pregnancies 
      (p = 0.007). The maternal hypertension and/or HIV profile has no marked impact on 
      the fetal weight. CONCLUSION: Our results demonstrate an increase in the urinary 
      level of kidney injury molecule-1 and calbindin in PE, implicating their possible 
      value as biomarkers of kidney injury. We observed no differences in the levels of 
      KIM-1, IL-18, MCP-1 and calbindin based on HIV status. We propose that studies 
      with larger sample sizes using these markers be conducted to establish their use 
      as markers of diagnosing kidney injury in PE.
FAU - Eltounali, Soumaya Abdullatif
AU  - Eltounali SA
AD  - a Optics and Imaging Centre, Nelson R. Mandela School of Medicine, College of 
      Health Sciences , University of KwaZulu-Natal , Durban , South Africa.
FAU - Moodley, Jagidesa
AU  - Moodley J
AD  - b Women's Health and HIV Research Unit, Nelson R. Mandela School of Medicine, 
      College of Health Sciences , University of KwaZulu-Natal , Durban , South Africa.
FAU - Naicker, Thajasvarie
AU  - Naicker T
AD  - a Optics and Imaging Centre, Nelson R. Mandela School of Medicine, College of 
      Health Sciences , University of KwaZulu-Natal , Durban , South Africa.
LA  - eng
PT  - Journal Article
DEP - 20171017
PL  - England
TA  - Hypertens Pregnancy
JT  - Hypertension in pregnancy
JID - 9421297
RN  - 0 (Biomarkers)
RN  - 0 (Calbindins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Biomarkers/urine
MH  - Calbindins/*urine
MH  - Chemokine CCL2/*urine
MH  - Female
MH  - HIV Infections/*urine
MH  - Hepatitis A Virus Cellular Receptor 1/*metabolism
MH  - Humans
MH  - Interleukin-18/*urine
MH  - Kidney Diseases/*diagnosis/urine
MH  - Pre-Eclampsia/*urine/virology
MH  - Pregnancy
MH  - South Africa
MH  - Young Adult
OTO - NOTNLM
OT  - Kidney injury molecule-1
OT  - Monocyte chemoattractant protein-1
OT  - calbindin
OT  - interleukin-18
EDAT- 2017/10/19 06:00
MHDA- 2018/07/18 06:00
CRDT- 2017/10/18 06:00
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/07/18 06:00 [medline]
PHST- 2017/10/18 06:00 [entrez]
AID - 10.1080/10641955.2017.1385793 [doi]
PST - ppublish
SO  - Hypertens Pregnancy. 2017 Nov;36(4):288-294. doi: 10.1080/10641955.2017.1385793. 
      Epub 2017 Oct 17.