PMID- 29040604
OWN - NLM
STAT- MEDLINE
DCOM- 20171212
LR  - 20230815
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 216
IP  - 9
DP  - 2017 Nov 27
TI  - Associations of Plasma Cytokine and Microbial Translocation Biomarkers With 
      Immune Reconstitution Inflammatory Syndrome.
PG  - 1159-1163
LID - 10.1093/infdis/jix460 [doi]
AB  - A nested case-cohort study was performed in participants of a clinical trial of 
      first-line human immunodeficiency virus treatments to investigate plasma 
      biomarkers of inflammation and microbial translocation for their association with 
      immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 
      participants with baseline CD4 count <350 cells/muL developed IRIS. Plasma from 51 
      IRIS cases, including 6 stratified by preenrollment CD4 count </=200 cells/muL, were 
      analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, 
      lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-alpha2 were 
      associated with greater risk of IRIS. Systemic inflammation through persistent 
      monocyte activation and microbial translocation appear to be important in IRIS 
      pathogenesis.
CI  - (c) The Author 2017. Published by Oxford University Press for the Infectious 
      Diseases Society of America. All rights reserved. For permissions, e-mail: 
      journals.permissions@oup.com.
FAU - George, Varghese
AU  - George V
AD  - Department of Microbiology and Immunology, University of Miami Miller School of 
      Medicine, Florida.
FAU - Harrison, Linda
AU  - Harrison L
AD  - Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public, 
      Boston, Massachusetts.
FAU - Roach, Margaret
AU  - Roach M
AD  - Department of Microbiology and Immunology, University of Miami Miller School of 
      Medicine, Florida.
FAU - Li, Xiao-Dong
AU  - Li XD
AD  - Department of Internal Medicine, University of California, Davis School of 
      Medicine, Sacramento.
FAU - Tierney, Camlin
AU  - Tierney C
AD  - Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public, 
      Boston, Massachusetts.
FAU - Fischl, Margaret A
AU  - Fischl MA
AD  - AIDS Clinical Research Unit, Department of Medicine, University of Miami Miller 
      School of Medicine, Florida.
FAU - Aberg, Judith
AU  - Aberg J
AD  - Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New 
      York, New York.
FAU - Tebas, Pablo
AU  - Tebas P
AD  - Division of Infectious Diseases, Department of Medicine, University of 
      Pennsylvania Perelman School of Medicine, Philadelphia.
FAU - Asmuth, David M
AU  - Asmuth DM
AD  - Department of Internal Medicine, University of California, Davis School of 
      Medicine, Sacramento.
FAU - Pollard, Richard B
AU  - Pollard RB
AD  - Department of Internal Medicine, University of California, Davis School of 
      Medicine, Sacramento.
FAU - Godfrey, Catherine
AU  - Godfrey C
AD  - Division of AIDS, National Institute of Allergy and Infectious Diseases, National 
      Institutes of Health, Bethesda, Maryland.
FAU - Pahwa, Savita
AU  - Pahwa S
AD  - Department of Microbiology and Immunology, University of Miami Miller School of 
      Medicine, Florida.
CN  - AIDS Clinical Trials Group A5202 Study Team
LA  - eng
GR  - P30 AI073961/AI/NIAID NIH HHS/United States
GR  - U01 AI068636/AI/NIAID NIH HHS/United States
GR  - UM1 AI068634/AI/NIAID NIH HHS/United States
GR  - UM1 AI069534/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Anti-HIV Agents/*therapeutic use
MH  - Biomarkers/*blood
MH  - Cohort Studies
MH  - Cytokines/*blood
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*blood/*immunology
MH  - Translocation, Genetic/*immunology
PMC - PMC5853564
OTO - NOTNLM
OT  - IRIS
OT  - cytokines
OT  - immune reconstitution inflammatory syndrome
OT  - microbial translocation
EDAT- 2017/10/19 06:00
MHDA- 2017/12/13 06:00
PMCR- 2018/11/27
CRDT- 2017/10/18 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/12/13 06:00 [medline]
PHST- 2017/10/18 06:00 [entrez]
PHST- 2018/11/27 00:00 [pmc-release]
AID - 4523862 [pii]
AID - jix460 [pii]
AID - 10.1093/infdis/jix460 [doi]
PST - ppublish
SO  - J Infect Dis. 2017 Nov 27;216(9):1159-1163. doi: 10.1093/infdis/jix460.