PMID- 29040763
OWN - NLM
STAT- MEDLINE
DCOM- 20180627
LR  - 20191210
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 12
IP  - 12
DP  - 2017 Dec 1
TI  - Oxytocin effects on self-referential processing: behavioral and neuroimaging 
      evidence.
PG  - 1845-1858
LID - 10.1093/scan/nsx116 [doi]
AB  - Oxytocin (OT) influences other-oriented mental processes (e.g. trust and empathy) 
      and the underlying neural substrates. However, whether and how OT modulates 
      self-oriented processes and the underlying brain activity remains unclear. Using 
      a double-blind, placebo-controlled between-subjects design, we manipulated memory 
      encoding and retrieval of trait adjectives related to the self, a friend and a 
      celebrity in a self-referential task in male adults. Experiment 1 (N = 51) found 
      that OT vs placebo treatments reduced response times during encoding self-related 
      trait adjectives but increased recognition scores of self-related information 
      during memory retrieval. Experiment 2 (N = 50) showed similar OT effects on 
      response times during encoding self-related trait adjectives. Moreover, 
      functional magnetic resonance imaging (fMRI) results revealed that OT vs placebo 
      treatments decreased the activity in the medial prefrontal cortex (MPFC) involved 
      in encoding of self-related trait adjectives and weakened the coupling between 
      the MPFC activity and a cultural trait (i.e. interdependence). Experiment 3 
      (N = 52) revealed that OT vs placebo treatments increased the right superior 
      frontal activity during memory retrieval of self-related information. The results 
      provide behavioral and fMRI evidence for OT effects on self-referential 
      processing and suggest distinct patterns of OT modulations of brain activities 
      engaged in encoding and retrieval of self-related information.
CI  - (c) The Author (2017). Published by Oxford University Press.
FAU - Liu, Yi
AU  - Liu Y
AD  - School of Psychological and Cognitive Sciences.
AD  - PKU-IDG/McGovern Institute for Brain Research.
AD  - Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 
      China.
FAU - Wu, Bing
AU  - Wu B
AD  - Department of Radiology, PLA Army General Hospital, Beijing, China.
FAU - Wang, Xuena
AU  - Wang X
AD  - School of Psychological and Cognitive Sciences.
AD  - PKU-IDG/McGovern Institute for Brain Research.
AD  - Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 
      China.
FAU - Li, Wenxin
AU  - Li W
AD  - Academy for Advanced Interdisciplinary Studies.
AD  - Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.
FAU - Zhang, Ting
AU  - Zhang T
AD  - School of Psychological and Cognitive Sciences.
AD  - PKU-IDG/McGovern Institute for Brain Research.
AD  - Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 
      China.
FAU - Wu, Xinhuai
AU  - Wu X
AD  - Department of Radiology, PLA Army General Hospital, Beijing, China.
FAU - Han, Shihui
AU  - Han S
AD  - School of Psychological and Cognitive Sciences.
AD  - PKU-IDG/McGovern Institute for Brain Research.
AD  - Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, 
      China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - Adult
MH  - Behavior/*drug effects
MH  - Brain Mapping
MH  - Culture
MH  - Double-Blind Method
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Recall/drug effects
MH  - Neuroimaging
MH  - Oxytocin/*pharmacology
MH  - Prefrontal Cortex/drug effects
MH  - Reaction Time/drug effects
MH  - Recognition, Psychology/drug effects
MH  - *Self Concept
MH  - Young Adult
PMC - PMC5716198
OTO - NOTNLM
OT  - encoding
OT  - fMRI
OT  - medial prefrontal cortex
OT  - oxytocin
OT  - self-referential processing
EDAT- 2017/10/19 06:00
MHDA- 2018/06/28 06:00
PMCR- 2017/10/04
CRDT- 2017/10/18 06:00
PHST- 2017/05/15 00:00 [received]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/06/28 06:00 [medline]
PHST- 2017/10/18 06:00 [entrez]
PHST- 2017/10/04 00:00 [pmc-release]
AID - 4344827 [pii]
AID - nsx116 [pii]
AID - 10.1093/scan/nsx116 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2017 Dec 1;12(12):1845-1858. doi: 10.1093/scan/nsx116.