PMID- 29042269
OWN - NLM
STAT- MEDLINE
DCOM- 20180618
LR  - 20180618
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 183
DP  - 2018 Jan 1
TI  - The comparison of acute high-intensity interval exercise vs. continuous 
      moderate-intensity exercise on plasma calprotectin and associated inflammatory 
      mediators.
PG  - 27-32
LID - S0031-9384(17)30354-2 [pii]
LID - 10.1016/j.physbeh.2017.10.015 [doi]
AB  - PURPOSE: Calprotectin promotes the release of inflammatory mediators (e.g., 
      monocyte chemoattractant protein-1 [MCP-1] and myeloperoxidase [MPO]) during the 
      innate immune response as a mechanism to augment leukocyte chemotaxis and 
      phagocytosis. Although plasma calprotectin is elevated with traditional 
      continuous moderate-intensity exercise (CME) as an indicator of the inflammatory 
      response, high-intensity interval exercise (HIIE) has been shown to attenuate 
      systemic inflammation while providing similar improvements in cardiovascular 
      health. Therefore, the purpose of this study was to compare plasma levels of 
      calprotectin, MCP-1, and MPO between acute HIIE vs. CME. METHODS: Nine healthy 
      males (24.67+/-3.27yrs) were recruited to participate in HIIE and CME on a cycle 
      ergometer. HIIE consisted of 10 repeated 60s of cycling at 90% max watts (W(max)) 
      separated by 2min of active recovery intensity of interval exercise, whereas CME 
      consisted of 28min of cycling at 60% W(max). Blood samples were collected prior 
      to, immediately post, and 30 and 60min into recovery following exercise. RESULTS: 
      Acute HIIE elicited a lower elevation in calprotectin and MPO compared to CME. An 
      increase in MCP-1 was observed across time in both exercise protocols. 
      Furthermore, our analyses did not reveal any significant correlation in percent 
      change (baseline to immediately following exercise) among calprotectin, MCP1, and 
      MPO in neither HIIE nor CME. However, a significant positive correlation was 
      observed in the overall release of calprotectin and MPO across all four time 
      points in both HIIE and CME. Conclusions Our findings indicate that acute HIIE 
      may potentially diminish the systemic release of inflammatory mediators 
      (calprotectin and MPO) compared to CME.
CI  - Published by Elsevier Inc.
FAU - Fico, Brandon G
AU  - Fico BG
AD  - Exercise Biochemistry Laboratory, Department of Exercise Science and Health 
      Promotion, Florida Atlantic University, Boca Raton, FL 33431, United States.
FAU - Whitehurst, Michael
AU  - Whitehurst M
AD  - Exercise Biochemistry Laboratory, Department of Exercise Science and Health 
      Promotion, Florida Atlantic University, Boca Raton, FL 33431, United States.
FAU - Slusher, Aaron L
AU  - Slusher AL
AD  - Exercise Biochemistry Laboratory, Department of Exercise Science and Health 
      Promotion, Florida Atlantic University, Boca Raton, FL 33431, United States; 
      Department of Kinesiology and Health Sciences, Virginia Commonwealth University, 
      Richmond, VA 23284, United States.
FAU - Mock, James T
AU  - Mock JT
AD  - Exercise Biochemistry Laboratory, Department of Exercise Science and Health 
      Promotion, Florida Atlantic University, Boca Raton, FL 33431, United States.
FAU - Maharaj, Arun
AU  - Maharaj A
AD  - Exercise Biochemistry Laboratory, Department of Exercise Science and Health 
      Promotion, Florida Atlantic University, Boca Raton, FL 33431, United States; 
      Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX 
      79409, United States.
FAU - Dodge, Katelyn M
AU  - Dodge KM
AD  - Exercise Biochemistry Laboratory, Department of Exercise Science and Health 
      Promotion, Florida Atlantic University, Boca Raton, FL 33431, United States.
FAU - Huang, Chun-Jung
AU  - Huang CJ
AD  - Exercise Biochemistry Laboratory, Department of Exercise Science and Health 
      Promotion, Florida Atlantic University, Boca Raton, FL 33431, United States. 
      Electronic address: chuang5@fau.edu.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20171016
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Leukocyte L1 Antigen Complex)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exercise/*physiology
MH  - Exercise Therapy
MH  - Humans
MH  - Inflammation/blood/therapy
MH  - Leukocyte L1 Antigen Complex/*blood
MH  - Male
MH  - Peroxidase/blood
MH  - Random Allocation
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Calprotectin
OT  - High-intensity interval exercise
OT  - Inflammation
OT  - Monocyte chemoattractant Protein-1
OT  - Myeloperoxidase
EDAT- 2017/10/19 06:00
MHDA- 2018/06/19 06:00
CRDT- 2017/10/19 06:00
PHST- 2017/06/03 00:00 [received]
PHST- 2017/08/27 00:00 [revised]
PHST- 2017/10/13 00:00 [accepted]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/06/19 06:00 [medline]
PHST- 2017/10/19 06:00 [entrez]
AID - S0031-9384(17)30354-2 [pii]
AID - 10.1016/j.physbeh.2017.10.015 [doi]
PST - ppublish
SO  - Physiol Behav. 2018 Jan 1;183:27-32. doi: 10.1016/j.physbeh.2017.10.015. Epub 
      2017 Oct 16.