PMID- 29042702
OWN - NLM
STAT- MEDLINE
DCOM- 20180612
LR  - 20221207
IS  - 0386-300X (Print)
IS  - 0386-300X (Linking)
VI  - 71
IP  - 5
DP  - 2017 Oct
TI  - Genetic Factors of Low-responsiveness to Hepatitis B Virus Vaccine Confirms the 
      Importance of Human Leukocyte Antigen Class II Types in a Japanese Young Adult 
      Population.
PG  - 433-436
LID - 10.18926/AMO/55442 [doi]
AB  - We investigated the genetic mechanisms underlying the association between human 
      leukocyte antigen (HLA) types and the immune response to hepatitis B virus (HBV) 
      vaccination in 84 healthy Japanese adults, and found that the HLA-DRB1＊04 and 
      HLA-DQB1＊03 frequencies were higher in the low responders (<10 mIU/ml; n=9, 
      10.7%) compared to the responders (>/=10 mIU/ml, n=75, 89.3%). The combination of 
      DRB1＊04 and DQB1＊03 was associated with a low response to vaccination. The 
      DRB1＊04 and DQB1＊03 haplotypes' frequencies were significantly higher in the low 
      responders compared to responders. Novel candidate HLA types may be important in 
      Japanese individuals.
FAU - Yukimasa, Nobuyasu
AU  - Yukimasa N
AD  - Department of Medical Technology, Kagawa Prefectural University of Health 
      Sciences, Takamatsu 761-0123, Japan.
FAU - Kohama, Shota
AU  - Kohama S
FAU - Oboshi, Wataru
AU  - Oboshi W
FAU - Sato, Shoichi
AU  - Sato S
FAU - Nakamura, Takehiro
AU  - Nakamura T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Acta Med Okayama
JT  - Acta medica Okayama
JID - 0417611
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
RN  - 0 (Hepatitis B Vaccines)
SB  - IM
MH  - Antibodies, Viral
MH  - *Asian People
MH  - Female
MH  - Gene Expression Regulation/immunology
MH  - HLA Antigens/*classification
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Hepatitis B/*prevention & control
MH  - Hepatitis B Vaccines/administration & dosage/*immunology
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic
MH  - Young Adult
OTO - NOTNLM
OT  - HBV vaccine
OT  - HLA class II
OT  - Japanese
OT  - antibody response
OT  - low-responder
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2017/10/19 06:00
MHDA- 2018/06/13 06:00
CRDT- 2017/10/19 06:00
PHST- 2017/10/19 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/06/13 06:00 [medline]
AID - 10.18926/AMO/55442 [doi]
PST - ppublish
SO  - Acta Med Okayama. 2017 Oct;71(5):433-436. doi: 10.18926/AMO/55442.