PMID- 29042830
OWN - NLM
STAT- MEDLINE
DCOM- 20180228
LR  - 20220316
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 14
DP  - 2017
TI  - Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on 
      physical and psychomotor performance.
PG  - 39
LID - 10.1186/s12970-017-0196-5 [doi]
LID - 39
AB  - BACKGROUND: Recent studies have suggested that alpha glycerylphosphorylcholine 
      (A-GPC) may be an effective ergogenic aid. The present study was designed to 
      assess the efficacy of two doses of A-GPC in comparison to placebo and caffeine 
      for increasing countermovement jump performance, isometric strength, and 
      psychomotor function. METHODS: Forty-eight healthy, college aged males 
      volunteered for the present study and underwent baseline assessment of 
      countermovement jump (CMJ), isometric mid thigh pull (IMTP), upper body isometric 
      strength test (UBIST), and psychomotor vigilance (PVT). Following this assessment 
      participants were randomly assigned to groups consisting of 500 mg A-GPC, 250 mg 
      A-GPC, 200 mg Caffeine or Placebo taken daily. Blood samples were collected 1 h 
      and 2 h post initial dose to quantify serum free choline and thyroid stimulating 
      hormone then subjects returned after 7 days of supplementation to repeat CMJ, 
      IMTP, UBIST and PVT. RESULTS: No differences were noted between groups for IMTP, 
      UBIST or PVT performance. Serum free choline was found to be elevated in the two 
      A-GPC groups as compared to placebo (132% and 59% respectively). Serum TSH was 
      found to be significantly depressed in the 500 mg A-GPC group compared to other 
      treatments (p < 0.04). Group differences were noted for maximum velocity and 
      maximum mechanical power on the CMJ (p < 0.05) with the 250 mg A-GPC group 
      demonstrating the greatest improvements in result. CONCLUSIONS: Based upon this 
      evidence, and previous evidence regarding A-GPC, it should be considered as an 
      emerging ergogenic supplement.
FAU - Marcus, Lena
AU  - Marcus L
AD  - School of Kinesiology, University of Louisiana at Lafayette, Lafayette, LA 70503 
      USA. ISNI: 0000 0000 9831 5270. GRID: grid.266621.7
FAU - Soileau, Jason
AU  - Soileau J
AD  - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 
      LA 70808 USA. ISNI: 0000 0001 0662 7451. GRID: grid.64337.35
FAU - Judge, Lawrence W
AU  - Judge LW
AD  - School of Kinesiology, Ball State University, Muncie, IN 47306 USA. ISNI: 0000 
      0001 2111 9017. GRID: grid.252754.3
FAU - Bellar, David
AU  - Bellar D
AUID- ORCID: 0000-0001-8273-1373
AD  - School of Kinesiology, University of Louisiana at Lafayette, Lafayette, LA 70503 
      USA. ISNI: 0000 0000 9831 5270. GRID: grid.266621.7
AD  - School of Kinesiology, University of Louisiana at Lafayette, 225 Cajundome Blvd, 
      Lafayette, LA 70506 USA. ISNI: 0000 0000 9831 5270. GRID: grid.266621.7
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20171005
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
RN  - 60M22SGW66 (Glycerylphosphorylcholine)
SB  - IM
MH  - Athletic Performance/*physiology
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Glycerylphosphorylcholine/*administration & dosage/*pharmacology
MH  - Healthy Volunteers
MH  - Humans
MH  - Isometric Contraction/drug effects/physiology
MH  - Male
MH  - Muscle Strength/drug effects/physiology
MH  - Psychomotor Performance/*drug effects/physiology
MH  - Reproducibility of Results
MH  - Sports Nutritional Physiological Phenomena
MH  - Young Adult
PMC - PMC5629791
OTO - NOTNLM
OT  - Power
OT  - Reaction time
OT  - Strength
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The present study was reviewed and 
      approved by the Institutional Review Board at the University of Louisiana at 
      Lafayette. All participants gave written informed consent prior to being enrolled 
      in the study. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The 
      authors declare that they have no competing interests. No person employed by or 
      affiliated with Chemi Nutra had any role in the design of the study, 
      interpretation of the data or development of the manuscript. PUBLISHER'S NOTE: 
      Springer Nature remains neutral with regard to jurisdictional claims in published 
      maps and institutional affiliations.
EDAT- 2017/10/19 06:00
MHDA- 2018/03/01 06:00
PMCR- 2017/10/05
CRDT- 2017/10/19 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/09/28 00:00 [accepted]
PHST- 2017/10/19 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/03/01 06:00 [medline]
PHST- 2017/10/05 00:00 [pmc-release]
AID - 196 [pii]
AID - 10.1186/s12970-017-0196-5 [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2017 Oct 5;14:39. doi: 10.1186/s12970-017-0196-5. 
      eCollection 2017.