PMID- 29042908
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 4
DP  - 2017 Oct
TI  - Nursing interventions in depressed children with low serum levels of BDNF.
PG  - 2947-2952
LID - 10.3892/etm.2017.4921 [doi]
AB  - The purpose of this study was to investigate the correlation between 
      brain-derived neurotrophic factor (BDNF) in serum and depression in children, and 
      explore the effects of different nursing protocols on patients with low levels of 
      BDNF. We recruited 128 children with depression and 50 healthy subjects. Compared 
      with healthy controls, the mRNA and protein levels of BDNF in serum were lower in 
      children with depression (p<0.01). We selected 60 depressed children with low 
      BDNF and randomly divided them in two groups: comprehensive nursing (n=30) and 
      regular nursing (n=30). Compared to healthy children, there was a significant 
      increase in Hamilton depression (HAMD) scores in patients with depression in 
      childhood (p<0.01). After treatment, BDNF protein expression was higher in the 
      comprehensive nursing group than that in the regular nursing group (p<0.05). 
      Also, the HAMD score in the comprehensive nursing group was significantly lower 
      than that in the regular nursing group (p<0.05). Compliance to treatment and 
      quality of life after treatment improved in the comprehensive nursing group 
      compared with the regular nursing group (p<0.05). Overall, a decrease in BDNF 
      expression is closely correlated with depression, and comprehensive nursing care 
      can significantly ameliorate the depression symptoms in pediatric patients, 
      increase the BDNF expression, and improve compliance and quality of life. These 
      results provide theoretical and practical significance for clinical nursing care 
      of patients with depression in childhood.
FAU - Sun, Qingrong
AU  - Sun Q
AD  - Department of Pediatrics, Binzhou City Center Hospital, Binzhou, Shandong 251700, 
      P.R. China.
FAU - Cui, Chuanying
AU  - Cui C
AD  - Department of Pediatrics, Binzhou City Center Hospital, Binzhou, Shandong 251700, 
      P.R. China.
FAU - Fu, Yanxia
AU  - Fu Y
AD  - Department of Pediatrics, Binzhou City Center Hospital, Binzhou, Shandong 251700, 
      P.R. China.
FAU - Ma, Shumei
AU  - Ma S
AD  - Department of Cardiovascular Medicine, Binzhou City Center Hospital, Binzhou, 
      Shandong 251700, P.R. China.
FAU - Li, Hongxia
AU  - Li H
AD  - Department of Obstetrics, Binzhou City Center Hospital, Binzhou, Shandong 251700, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170811
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5639410
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - comprehensive nursing care
OT  - depression
EDAT- 2017/10/19 06:00
MHDA- 2017/10/19 06:01
PMCR- 2017/08/11
CRDT- 2017/10/19 06:00
PHST- 2017/05/26 00:00 [received]
PHST- 2017/08/07 00:00 [accepted]
PHST- 2017/10/19 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/10/19 06:01 [medline]
PHST- 2017/08/11 00:00 [pmc-release]
AID - ETM-0-0-4921 [pii]
AID - 10.3892/etm.2017.4921 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Oct;14(4):2947-2952. doi: 10.3892/etm.2017.4921. Epub 2017 Aug 
      11.