PMID- 29042929
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 4
DP  - 2017 Oct
TI  - Quantitative assessment of salvaged myocardial zone and intramyocardial 
      hemorrhage using non-contrast faster T2 mapping in a rat model by 7T MRI.
PG  - 3425-3432
LID - 10.3892/etm.2017.4967 [doi]
AB  - The aim of this study was to determine the myocardial area at risk (AAR), 
      infarction-core size (IS) and the salvaged myocardial zone (SMZ), and to evaluate 
      the imaging and histological characteristics of intramyocardial hemorrhage (IMH) 
      after myocardial infarction using non-contrast T2 mapping on 7T magnetic 
      resonance imaging (MRI). Twenty Sprague Dawley (SD) rats were randomly divided 
      into the sham and model groups (n=10 in each). In the model group, myocardial 
      infarction models were established by left anterior descending branch ligation. 
      After 24 h, all animals were imaged on a 7.0 Tesla system with cine spiral 
      imaging, T2 mapping with late gadolinium enhancement (LGE). The rats were then 
      sacrificed for measurement of the IS and AAR using 2,3,5-triphenylterazolium 
      chloride (TTC) and hematoxylin and eosin (H&E) staining. T2 mapping revealed that 
      the AAR in the model group was significantly higher than that in the sham group. 
      No remarkable T2 value was noted in the entire heart of the sham group. LGE and 
      TTC staining demonstrated similar IS. T2 mapping and H&E staining revealed a 
      similar AAR as well. T2 mapping characterized the IMH as a phenomenon resulting 
      from the area of hypointensity in the hyperintensity involving the infarct-core 
      zone and corresponding T2 value 928.6+/-1.52 msec with IMH vs. 35.8+/-2.61 msec 
      without IMH; n=3 with 18 slices; P=0.032). In conclusion, non-contrast T2 mapping 
      was a reliable approach to quantitatively evaluate the SMZ and IMH.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Radiology, Affiliated Hospital of Guizhou Medical University, 
      Guiyang, Guizhou 550004, P.R. China.
AD  - Department of Radiology, General Hospital of PLA, Beijing 100853, P.R. China.
FAU - Xu, Yini
AU  - Xu Y
AD  - The Key Laboratory of Optional Utilization of Natural Medicinal Resources, 
      Guizhou Medical University, Huaxi University Town, Guiyang, Guizhou 550025, P.R. 
      China.
FAU - Wang, Lei
AU  - Wang L
AD  - Molecular Imaging Laboratory, Department of Radiology, West China Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Chen, Yushu
AU  - Chen Y
AD  - Molecular Imaging Laboratory, Department of Radiology, West China Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, P.R. China.
FAU - Tian, Ruiqing
AU  - Tian R
AD  - Department of Oncology, The First People's Hospital of Guiyang, Guiyang, Guizhou 
      550002, P.R. China.
FAU - Jiao, Jun
AU  - Jiao J
AD  - Department of Radiology, Affiliated Hospital of Guizhou Medical University, 
      Guiyang, Guizhou 550004, P.R. China.
FAU - Xie, Hong
AU  - Xie H
AD  - Department of Radiology, Affiliated Hospital of Guizhou Medical University, 
      Guiyang, Guizhou 550004, P.R. China.
FAU - Yang, Li
AU  - Yang L
AD  - Department of Radiology, General Hospital of PLA, Beijing 100853, P.R. China.
FAU - Gao, Fabao
AU  - Gao F
AD  - Molecular Imaging Laboratory, Department of Radiology, West China Hospital, 
      Sichuan University, Chengdu, Sichuan 610041, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170818
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5639411
OTO - NOTNLM
OT  - 7T MR imaging
OT  - intramyocardial hemorrhage
OT  - myocardial infarction
OT  - rat model
OT  - salvaged myocardial zone
EDAT- 2017/10/19 06:00
MHDA- 2017/10/19 06:01
PMCR- 2017/08/18
CRDT- 2017/10/19 06:00
PHST- 2016/07/05 00:00 [received]
PHST- 2017/03/24 00:00 [accepted]
PHST- 2017/10/19 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/10/19 06:01 [medline]
PHST- 2017/08/18 00:00 [pmc-release]
AID - ETM-0-0-4967 [pii]
AID - 10.3892/etm.2017.4967 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Oct;14(4):3425-3432. doi: 10.3892/etm.2017.4967. Epub 2017 Aug 
      18.