PMID- 29042973
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 4
DP  - 2017 Oct
TI  - The efficacy of microsurgery in the treatment of cerebral aneurysm rupture and 
      its effect on NF-kappaB, MCP-1 and MMP-9.
PG  - 3744-3748
LID - 10.3892/etm.2017.4928 [doi]
AB  - The clinical efficacy of microsurgical neck clipping for the treatment of 
      cerebral aneurysm rupture and its effect on serum nuclear factor 
      kappa-light-chain-enhancer of activated beta cells (NF-kappaB), monocyte chemoattractant 
      protein-1 (MCP-1) and matrix metalloproteinase-9 (MMP-9) levels were 
      investigated. A total of 56 patients with first occurrence of cerebral aneurysm 
      rupture were enrolled from June 2015 to June 2016. These patients were divided 
      into control (25 patients) and observation groups (31 patients) according to 
      treatment received. The patients in the control group were treated with 
      interventional embolization and extraventricular drainage, while the patients in 
      the observation group were treated with microsurgical neck clipping. Serum NF-kappaB, 
      MCP-1 and MMP-9 levels were measured by ELISA prior to the operation and at 6 h 
      post-operation. Clinical effects were compared at the 6-month follow-up. There 
      was no significant difference in the success rate of the operation between the 
      two groups (p>0.05). The incidence of complications in the observation group was 
      significantly lower than that in the control group (p<0.05). The Glasgow Outcome 
      Scale score was significantly improved in the observation group (p<0.05) compared 
      with the control group. Serum NF-kappaB, MMP-9 and MCP-1 were significantly decreased 
      in both groups at 6 and 24 h after operation, but the observational group showed 
      significantly lower levels for all three proteins than the control group 
      (p<0.05). The application of early microsurgical neck clipping for the treatment 
      of cerebral aneurysm rupture can reduce complications and improve clinical 
      prognosis, and this may be related to a decrease in serum inflammatory 
      response-related factors (NF-kappaB and MCP-1) and MMP-9.
FAU - Zhang, Xintong
AU  - Zhang X
AD  - The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, 
      P.R. China.
AD  - The Second Clinical Medical School of Inner Mongolia University for the 
      Nationalities, Yakeshi, Inner Mongolia 022150, P.R. China.
FAU - Chen, Lei
AU  - Chen L
AD  - Hulunbuir People's Hospital, Hulunbuir, Inner Mongolia 021000, P.R. China.
FAU - Zheng, Feng
AU  - Zheng F
AD  - Department of Neurosurgery, University Hospital of Cologne, D-50937 Cologne, 
      Germany.
AD  - Department of Cerebrovascular Disease, Affilliated Hospital of Zunyi Medical 
      College, Zunyi, Guizhou 563000, P.R. China.
FAU - Du, Yanli
AU  - Du Y
AD  - The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170814
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5639380
OTO - NOTNLM
OT  - MMP-9
OT  - NF-kappaB
OT  - cerebral aneurysm
OT  - interventional embolization
OT  - microsurgery
OT  - monocyte chemoattractant protein-1
EDAT- 2017/10/19 06:00
MHDA- 2017/10/19 06:01
PMCR- 2017/08/14
CRDT- 2017/10/19 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/10/19 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/10/19 06:01 [medline]
PHST- 2017/08/14 00:00 [pmc-release]
AID - ETM-0-0-4928 [pii]
AID - 10.3892/etm.2017.4928 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Oct;14(4):3744-3748. doi: 10.3892/etm.2017.4928. Epub 2017 Aug 
      14.