PMID- 29042992
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 4
DP  - 2017 Oct
TI  - Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum 
      depression by the regulation of inflammatory cytokines, BNDF signaling and 
      synaptic plasticity.
PG  - 3856-3861
LID - 10.3892/etm.2017.4930 [doi]
AB  - The aim of this study was to investigate the antidepressive effects of 
      timosaponin B-III (TB-III) and the underlying mechanism. A postpartum depression 
      (PPD) mouse model was established by the administration of dexamethasone sodium 
      phosphate during pregnancy. Mice with PPD were assigned to the following groups: 
      Model, fluoxetine and high, medium and low doses of TB-III. Post-parturient mice 
      without PPD served as a normal control group. To examine the effect of TB-III, 
      mice were treated with TB-III, then forced swimming tests (FSTs) and tail 
      suspension tests (TSTs) were performed to evaluate depression. Serum and 
      hippocampal cytokines, namely tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, 
      IL-6 and IL-10, were quantified using ELISAs and protein levels of hippocampal 
      brain-derived neurotrophic factor (BDNF), glucagon synthase kinase (GSK)-3beta, 
      glutamate receptor subunit 1 (GluR1), postsynaptic density protein 95 (PSD95) and 
      synapsin I were quantified using western blot analysis. Compared with those in 
      the control group, immobility time in the FST and TST, serum and hippocampal 
      TNF-alpha, IL-1beta and IL-6 levels and hippocampal IL-10 levels were increased 
      significantly in the model group (P<0.01). Serum IL-10 levels and hippocampal 
      levels of BDNF, GSK-3beta, GluR1, PSD95 and synapsin I decreased significantly in 
      the model group compared with the control group (P<0.01). Fluoxetine or TB-III 
      (10, 20 or 40 mg/kg) treatment significantly decreased immobility times in the 
      FST and TST (P<0.01) and significantly reversed the aforementioned alterations in 
      cytokine and protein levels (P<0.01). Thus, TB-III exhibited a protective effect 
      against depression in PPD and such effects may have been mediated via the 
      regulation of inflammatory cytokines, the BNDF signaling pathway and synaptic 
      plasticity-related proteins.
FAU - Zhang, Xiao-Li
AU  - Zhang XL
AD  - Department of Ultrasonography, Zhongnan Hospital of Wuhan University, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Wang, Lin
AU  - Wang L
AD  - Department of Histology and Embryology, Medical College of Wuhan University, 
      Wuhan, Hubei 430071, P.R. China.
FAU - Xiong, Li
AU  - Xiong L
AD  - Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 
      430071, P.R. China.
FAU - Huang, Feng-Hua
AU  - Huang FH
AD  - Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, 
      Wuhan, Hubei 430071, P.R. China.
FAU - Xue, Han
AU  - Xue H
AD  - Department of Clinical Laboratory, Zhongnan Hospital of Wuhan University, Wuhan, 
      Hubei 430071, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170814
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5639285
OTO - NOTNLM
OT  - bone-derived neurotrophic factor signaling pathway
OT  - depression
OT  - forced swimming test
OT  - inflammatory cytokines
OT  - synaptic plasticity
OT  - tail suspension test
OT  - timosaponin B-III
EDAT- 2017/10/19 06:00
MHDA- 2017/10/19 06:01
PMCR- 2017/08/14
CRDT- 2017/10/19 06:00
PHST- 2016/04/29 00:00 [received]
PHST- 2017/05/11 00:00 [accepted]
PHST- 2017/10/19 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/10/19 06:01 [medline]
PHST- 2017/08/14 00:00 [pmc-release]
AID - ETM-0-0-4930 [pii]
AID - 10.3892/etm.2017.4930 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Oct;14(4):3856-3861. doi: 10.3892/etm.2017.4930. Epub 2017 Aug 
      14.