PMID- 29044373
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20180713
IS  - 1878-3503 (Electronic)
IS  - 0035-9203 (Linking)
VI  - 111
IP  - 6
DP  - 2017 Jun 1
TI  - Antimicrobial resistance: a One Health perspective.
PG  - 255-260
LID - 10.1093/trstmh/trx050 [doi]
AB  - INTRODUCTION: Worsening antimicrobial resistance (AMR) threatens the practice of 
      modern human and veterinary medicine. For decades, medicine and agriculture have 
      blamed each other for the rise of resistant microbes. Widespread use and misuse 
      of antibiotics in both medicine and agriculture have increased the prevalence and 
      expression of resistance genes. VRE: The rise of vancomycin-resistant 
      Enterococcus faecium (VRE) in the European Union (EU) led to the ban of 
      avoparcin, an antibiotic that is chemically related to vancomycin. In the years 
      post-ban, VRE surveillance data of EU hospitals showed no obvious reduction in 
      VRE rates. The USA never approved avoparcin, yet VRE has been an enormous problem 
      in its hospitals. AMR surveillance data showed zero rates of VRE in US livestock. 
      Whole-genome sequencing data suggest that VRE might have evolved from 
      ampicillin-resistant E. faecium from dogs. Companion animals have been completely 
      ignored in the AMR debate. SANITATION: In addition, 1 billion people openly 
      defecate around the world. Of these, 60% live in India, a country with highly 
      resistant microbes. CONCLUSION: A One Health approach integrating human, animal 
      and environmental whole-genome sequencing surveillance data is essential to 
      getting to the root of AMR and developing effective prevention and control 
      strategies.
CI  - (c) The Author 2017. Published by Oxford University Press on behalf of Royal 
      Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Kahn, Laura H
AU  - Kahn LH
AD  - Research Scholar, Program on Science and Global Security, Woodrow Wilson School 
      of Public and International Affairs, Princeton University, NJ 08544, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Trans R Soc Trop Med Hyg
JT  - Transactions of the Royal Society of Tropical Medicine and Hygiene
JID - 7506129
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Glycopeptides)
RN  - WJ13O9MNTI (avoparcin)
SB  - IM
MH  - Ampicillin Resistance
MH  - Animal Diseases/*microbiology
MH  - Animals
MH  - *Anti-Bacterial Agents/therapeutic use
MH  - Bacterial Proteins/genetics
MH  - *Communicable Disease Control
MH  - Dogs/microbiology
MH  - *Drug Resistance, Bacterial/genetics
MH  - *Enterococcus faecium/genetics
MH  - Europe
MH  - Feces/microbiology
MH  - Glycopeptides/therapeutic use
MH  - Humans
MH  - India
MH  - Livestock/microbiology
MH  - *One Health
MH  - Pets/microbiology
MH  - Sanitation
MH  - United States
MH  - Vancomycin Resistance
MH  - *Vancomycin-Resistant Enterococci/genetics
MH  - Whole Genome Sequencing
OTO - NOTNLM
OT  - Antimicrobial resistance
OT  - One Health
OT  - Vancomycin-resistant Enterococcus faecium
OT  - Whole-genome sequencing
EDAT- 2017/10/19 06:00
MHDA- 2018/06/12 06:00
CRDT- 2017/10/19 06:00
PHST- 2017/03/08 00:00 [received]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/10/19 06:00 [entrez]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
AID - 4554993 [pii]
AID - 10.1093/trstmh/trx050 [doi]
PST - ppublish
SO  - Trans R Soc Trop Med Hyg. 2017 Jun 1;111(6):255-260. doi: 10.1093/trstmh/trx050.