PMID- 29044734
OWN - NLM
STAT- MEDLINE
DCOM- 20180920
LR  - 20180920
IS  - 1439-0272 (Electronic)
IS  - 0303-4569 (Linking)
VI  - 50
IP  - 3
DP  - 2018 Apr
TI  - Association of androgen receptor gene CAG and GGN repeat polymorphism with 
      cryptorchidism: A meta-analysis.
LID - 10.1111/and.12909 [doi]
AB  - Researches on association between variations in the androgen receptor (AR) gene 
      repeat polymorphisms and cryptorchidism (CO) had conflicting results. The aim of 
      this meta-analysis was to analyse the potential effects of AR CAG and/or GGN 
      repeat polymorphism on CO. Studies were independently appraised by two 
      investigators on PubMed, Web of Science, EBSCO databases and Foreign Medical 
      Retrieval System. Case-control studies with measurement of CAG and/or GGN repeat 
      length were included. Weighted mean difference (WMD) and 95% confidence intervals 
      (CIs) for the CAG or GGN repeat polymorphism and CO were calculated. Five reports 
      were included in this analysis. Overall, no difference was identified between 
      patients and fertile men in CAG repeat length. However, when the CO was divided 
      into unilateral and bilateral, longer CAG repeat region was significantly 
      associated with CO in bilateral group (WMD = 0.74; 95% CI, 0.01-1.47; p < .05). 
      In addition, GGN lengths were significantly higher in patients compared with 
      those in controls (WMD = 1.17; 95% CI, 0.28-2.06; p < .05). No obvious effect was 
      found in the GGN length when compared unilateral or bilateral group with control 
      respectively. The results in this meta-analysis indicated that AR CAG and GGN 
      repeat polymorphisms may be an important pathogenesis of CO.
CI  - (c) 2017 Blackwell Verlag GmbH.
FAU - Wang, Qi
AU  - Wang Q
AD  - School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Ge, Xing
AU  - Ge X
AD  - School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Wang, Heng-Xue
AU  - Wang HX
AD  - School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Shi, Qiao-Mei
AU  - Shi QM
AD  - School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Ding, Zhen
AU  - Ding Z
AD  - School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
FAU - Xu, Li-Chun
AU  - Xu LC
AUID- ORCID: 0000-0001-7694-0451
AD  - School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20171018
PL  - Germany
TA  - Andrologia
JT  - Andrologia
JID - 0423506
RN  - 0 (Receptors, Androgen)
SB  - IM
MH  - Cryptorchidism/*genetics
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Receptors, Androgen/*genetics
MH  - *Trinucleotide Repeats
OTO - NOTNLM
OT  - CAG repeat polymorphism
OT  - GGN repeat polymorphism
OT  - cryptorchidism
OT  - meta-analysis
EDAT- 2017/10/19 06:00
MHDA- 2018/09/21 06:00
CRDT- 2017/10/19 06:00
PHST- 2017/08/18 00:00 [accepted]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/09/21 06:00 [medline]
PHST- 2017/10/19 06:00 [entrez]
AID - 10.1111/and.12909 [doi]
PST - ppublish
SO  - Andrologia. 2018 Apr;50(3). doi: 10.1111/and.12909. Epub 2017 Oct 18.