PMID- 29044779
OWN - NLM
STAT- MEDLINE
DCOM- 20181019
LR  - 20181202
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 19
IP  - 3
DP  - 2018 May
TI  - Exocrine pancreas function decreases during the progression of the beta-cell 
      damaging process in young prediabetic children.
PG  - 398-402
LID - 10.1111/pedi.12592 [doi]
AB  - OBJECTIVE: The function of the exocrine pancreas is decreased in patients with 
      type 1 diabetes but it is not known when this defect develops. The current study 
      set out to determine whether the reduced exocrine function becomes manifest after 
      the initiation of islet autoimmunity. METHODS: The study was nested in the 
      prospective Type 1 Diabetes Prediction and Prevention study where children with 
      human leukocyte antigen (HLA)-conferred susceptibility are observed from birth. 
      Elastase-1 levels were analyzed from stool samples collected at the time of 
      seroconversion to islet autoantibody positivity and at diagnosis of type 1 
      diabetes, as well as from samples taken from matched control children of similar 
      age. RESULTS: Elastase levels were lower in case children at the time of the 
      diagnosis of diabetes when compared to the control children. However, elastase 
      concentrations did not differ between cases and controls at the time when 
      autoantibodies appeared. CONCLUSION: The results suggest that the defect in the 
      exocrine function develops after the appearance of islet autoantibodies. Further 
      studies are needed to assess whether reduced elastase levels predict rapid 
      progression of islet autoimmunity to clinical disease.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kondrashova, Anita
AU  - Kondrashova A
AUID- ORCID: 0000-0001-8012-9135
AD  - Department of Virology, School of Medicine, University of Tampere, Tampere, 
      Finland.
FAU - Nurminen, Noora
AU  - Nurminen N
AD  - Department of Virology, School of Medicine, University of Tampere, Tampere, 
      Finland.
FAU - Lehtonen, Jussi
AU  - Lehtonen J
AD  - Department of Virology, School of Medicine, University of Tampere, Tampere, 
      Finland.
FAU - Hyoty, Marja
AU  - Hyoty M
AD  - Department of Gastroenterology and Alimentary Tract Surgery, Tampere University 
      Hospital, Tampere, Finland.
FAU - Toppari, Jorma
AU  - Toppari J
AD  - Department of Physiology, Institute of Biomedicine, University of Turku, Turku, 
      Finland.
AD  - Department of Pediatrics, Turku University Hospital, Turku, Finland.
FAU - Ilonen, Jorma
AU  - Ilonen J
AD  - Immunogenetics Laboratory, University of Turku and Turku University Hospital, 
      Turku, Finland.
FAU - Veijola, Riitta
AU  - Veijola R
AD  - Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, Oulu 
      University Hospital and University of Oulu, Oulu, Finland.
FAU - Knip, Mikael
AU  - Knip M
AUID- ORCID: 0000-0003-0474-0033
AD  - Children's Hospital, University of Helsinki and Helsinki University Hospital, 
      Helsinki, Finland.
AD  - Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, 
      Finland.
AD  - Tampere Center for Child Health Research, Tampere University Hospital, Tampere, 
      Finland.
AD  - Folkhalsan Research Center, Helsinki, Finland.
FAU - Hyoty, Heikki
AU  - Hyoty H
AD  - Department of Virology, School of Medicine, University of Tampere, Tampere, 
      Finland.
AD  - Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171017
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - EC 3.4.21.36 (Pancreatic Elastase)
SB  - IM
MH  - Adolescent
MH  - Autoimmunity
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/immunology/*physiopathology
MH  - Feces/enzymology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Pancreas/immunology/*metabolism/physiopathology
MH  - Pancreatic Elastase/analysis
MH  - Prediabetic State/immunology/*physiopathology
OTO - NOTNLM
OT  - autoantibodies
OT  - pancreatic elastase
OT  - prediabetic state
OT  - seroconversion
OT  - type 1 diabetes mellitus
EDAT- 2017/10/19 06:00
MHDA- 2018/10/20 06:00
CRDT- 2017/10/19 06:00
PHST- 2017/02/02 00:00 [received]
PHST- 2017/08/31 00:00 [revised]
PHST- 2017/09/11 00:00 [accepted]
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
PHST- 2017/10/19 06:00 [entrez]
AID - 10.1111/pedi.12592 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2018 May;19(3):398-402. doi: 10.1111/pedi.12592. Epub 2017 Oct 
      17.