PMID- 29045333
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20181202
IS  - 1536-481X (Electronic)
IS  - 1057-0829 (Linking)
VI  - 26
IP  - 12
DP  - 2017 Dec
TI  - Relationship Between Optic Nerve Head Drusen Volume and Structural and Functional 
      Optic Nerve Damage.
PG  - 1095-1100
LID - 10.1097/IJG.0000000000000783 [doi]
AB  - PURPOSE: The purpose of this study is to assess the relationships between optic 
      nerve head drusen (ONHD) volume, retinal nerve fiber layer (RNFL) thickness and 
      visual field (VF) loss. METHODS: Patients with ONHD and no other ocular or 
      systemic conditions that can affect RNFL or VF were enrolled. Serial enhanced 
      depth imaging (EDI) optical coherence tomography (OCT) B-scans of the optic nerve 
      head (interval between scans, ~30 mum) were obtained from each participant. ONHD 
      volume was calculated for each eye by delineating the ONHD masses in each OCT 
      B-scan using 3-dimensional reconstruction software. RESULTS: A total of 47 eyes 
      (28 patients) with ONHD were included (mean age, 57+/-16 y). ONHD volume varied 
      considerably [0.265+/-0.227 (range, 0.005 to 0.855)] mm. Linear and quadratic 
      regression analyses demonstrated that ONHD volume is significantly associated 
      with both global average RNFL thickness (linear R=0.531, quadratic R=0.557; 
      P<0.001) and VF mean deviation (linear R=0.519, quadratic R=0.522; P<0.001). ONHD 
      were most prevalent in the nasal quadrant (46 eyes, 98%), followed by superior, 
      inferior and temporal quadrants [35 (74%), 30 (64%), and 16 (34%) eyes 
      respectively]. The proportion of eyes with OCT RNFL defects (81%; 38/47 eyes) was 
      significantly greater than that with VF defects (60%; 28/47 eyes) (P<0.001). RNFL 
      defects were detected in 10 of the 19 eyes with no VF defects. RNFL defects were 
      detected in all 28 eyes with VF defects. CONCLUSIONS: ONHD volume generally 
      correlates with structural and functional optic nerve damage.
FAU - Skaat, Alon
AU  - Skaat A
AD  - Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical 
      Research Center, New York Eye and Ear Infirmary of Mount Sinai.
AD  - Goldschleger Eye Institute, Sheba Medical Center, Sackler Faculty of Medicine, 
      Tel Aviv University, Tel Aviv, Israel.
FAU - Muylaert, Stephanie
AU  - Muylaert S
AD  - Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical 
      Research Center, New York Eye and Ear Infirmary of Mount Sinai.
FAU - Mogil, Rachel S
AU  - Mogil RS
AD  - Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital.
AD  - Department of Ophthalmology, Zucker School of Medicine at Hofstra/Northwell, 
      Hempstead, NY.
FAU - Furlanetto, Rafael L
AU  - Furlanetto RL
AD  - Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical 
      Research Center, New York Eye and Ear Infirmary of Mount Sinai.
FAU - Netto, Camila F
AU  - Netto CF
AD  - Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical 
      Research Center, New York Eye and Ear Infirmary of Mount Sinai.
FAU - Banik, Rudrani
AU  - Banik R
AD  - Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical 
      Research Center, New York Eye and Ear Infirmary of Mount Sinai.
AD  - Icahn School of Medicine at Mount Sinai.
FAU - Liebmann, Jeffrey M
AU  - Liebmann JM
AD  - Bernard and Shirlee Brown Glaucoma Research Laboratory, Harkness Eye Institute, 
      Columbia University Medical Center, New York.
FAU - Ritch, Robert
AU  - Ritch R
AD  - Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical 
      Research Center, New York Eye and Ear Infirmary of Mount Sinai.
FAU - Park, Sung Chul
AU  - Park SC
AD  - Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital.
AD  - Department of Ophthalmology, Zucker School of Medicine at Hofstra/Northwell, 
      Hempstead, NY.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology/physiopathology
MH  - Optic Disk Drusen/*diagnosis/physiopathology
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
MH  - Young Adult
EDAT- 2017/10/19 06:00
MHDA- 2017/12/27 06:00
CRDT- 2017/10/19 06:00
PHST- 2017/10/19 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2017/10/19 06:00 [entrez]
AID - 10.1097/IJG.0000000000000783 [doi]
PST - ppublish
SO  - J Glaucoma. 2017 Dec;26(12):1095-1100. doi: 10.1097/IJG.0000000000000783.