PMID- 29046192
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20180625
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 38
IP  - 6
DP  - 2017 Nov 1
TI  - Management of adverse reactions to biologic agents.
PG  - 409-418
LID - 10.2500/aap.2017.38.4085 [doi]
AB  - Hypersensitivity reactions (HSR) to targeted biologic agents present as immediate 
      reactions during infusion or as delayed reactions (after one or more exposures). 
      The new classification includes phenotypes, endotypes, and biomarkers. Phenotypes 
      include immediate type I (immunoglobulin E [IgE] or non-IgE mediated), cytokine 
      release, mixed (type I/cytokine), and immune complexes type III (IgG mediated) 
      reactions as well as delayed type IV reactions. Endotypes include IgE or non-IgE 
      mediated mast cells/basophils activation with elevated serum tryptase and T cells 
      values as well as macrophages, which lead to cytokine production, e.g., 
      interleukin 6. A skin test is a valuable tool in evaluating HSRs to biologics; 
      however, its predictive value depends on the type of reaction and the monoclonal 
      antibody. Desensitization is a new approach to safely reintroduce biologics when 
      they are first-line therapies, and it is available for immediate and delayed 
      reactions. Research is needed to further understand the mechanisms of reactions 
      to monoclonal antibodies and their management.
FAU - Isabwe, Ghislaine Annie C
AU  - Isabwe GAC
FAU - de Las Vecillas Sanchez, Leticia
AU  - de Las Vecillas Sanchez L
FAU - Castells, Mariana
AU  - Castells M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Biological Factors)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biological Factors/*adverse effects/immunology/therapeutic use
MH  - Biomarkers
MH  - Desensitization, Immunologic/*methods
MH  - Drug Hypersensitivity/*therapy
MH  - Humans
MH  - Phenotype
EDAT- 2017/10/20 06:00
MHDA- 2018/06/26 06:00
CRDT- 2017/10/20 06:00
PHST- 2017/10/20 06:00 [entrez]
PHST- 2017/10/20 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
AID - 10.2500/aap.2017.38.4085 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2017 Nov 1;38(6):409-418. doi: 10.2500/aap.2017.38.4085.