PMID- 29046788
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2049-9450 (Print)
IS  - 2049-9469 (Electronic)
IS  - 2049-9450 (Linking)
VI  - 7
IP  - 4
DP  - 2017 Oct
TI  - A rare case of dedifferentiated liposarcoma of the sinonasal cavity: A case 
      report.
PG  - 539-542
LID - 10.3892/mco.2017.1379 [doi]
AB  - Sarcoma is an uncommon histopathological presentation of sinonasal tumors, 
      comprising ~15% of all cases; liposarcoma is particularly uncommon. An analysis 
      of the available medical literature revealed no prior reports of dedifferentiated 
      liposarcoma (DDLPS) of the sinonasal cavity. This case report presents a rare 
      case of DDLPS of the sinonasal cavity. A 40-year old six-week pregnant female was 
      admitted with a left nasal obstruction. Endoscopic evaluation of the left nasal 
      cavity revealed a polypoid lesion. A computed tomography scan indicated a mass 
      invading the left nasal cavity, maxillary sinus and anterior ethmoid sinus with 
      focal destruction of the surrounding bone. A biopsy of the tumor was performed 
      and hematoxylin and eosin staining of the tissue sections revealed proliferation 
      of atypical and pleomorphic spindle cells with enlarged or elongated 
      hyperchromatic nuclei and occasional vacuolated cytoplasm arranged in short 
      interlacing fascicles or storiform structures, accompanied by tumor necrosis. 
      These findings were consistent with undifferentiated pleomorphic sarcoma. 
      Immunohistochemically, the tumor cells were positive for cyclin dependent kinase 
      4, mouse double minute 2 homolog (MDM2) and adipophilin. Fluorescence in situ 
      hybridization (FISH) analysis revealed amplification of the MDM2 gene. Recently, 
      undifferentiated pleomorphic sarcoma without areas of well-differentiated 
      liposarcoma but with MDM2 amplification is regarded as conventional DDLPS. In the 
      present case, the tumor was diagnosed as a DDLPS due to the results of 
      histopathological, immunohistochemical and FISH analysis.
FAU - Miyazaki, Masaru
AU  - Miyazaki M
AD  - Department of Pathology, Fukuoka University School of Medicine, Fukuoka 814-0180, 
      Japan.
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University 
      School of Medicine, Fukuoka 814-0180, Japan.
FAU - Aoki, Mikiko
AU  - Aoki M
AD  - Department of Pathology, Fukuoka University School of Medicine, Fukuoka 814-0180, 
      Japan.
FAU - Oba, Satoru
AU  - Oba S
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University 
      School of Medicine, Fukuoka 814-0180, Japan.
FAU - Sakata, Toshifumi
AU  - Sakata T
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University 
      School of Medicine, Fukuoka 814-0180, Japan.
FAU - Nakagawa, Takashi
AU  - Nakagawa T
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Fukuoka University 
      School of Medicine, Fukuoka 814-0180, Japan.
FAU - Nabeshima, Kazuki
AU  - Nabeshima K
AD  - Department of Pathology, Fukuoka University School of Medicine, Fukuoka 814-0180, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20170818
PL  - England
TA  - Mol Clin Oncol
JT  - Molecular and clinical oncology
JID - 101613422
PMC - PMC5639279
OTO - NOTNLM
OT  - adipophilin
OT  - cyclin dependent kinase 4
OT  - dedifferentiated liposarcoma
OT  - fluorescence in situ hybridization
OT  - mouse double minute 2 homolog
OT  - sinonasal cavity
EDAT- 2017/10/20 06:00
MHDA- 2017/10/20 06:01
PMCR- 2017/08/18
CRDT- 2017/10/20 06:00
PHST- 2017/01/31 00:00 [received]
PHST- 2017/05/19 00:00 [accepted]
PHST- 2017/10/20 06:00 [entrez]
PHST- 2017/10/20 06:00 [pubmed]
PHST- 2017/10/20 06:01 [medline]
PHST- 2017/08/18 00:00 [pmc-release]
AID - MCO-0-0-1379 [pii]
AID - 10.3892/mco.2017.1379 [doi]
PST - ppublish
SO  - Mol Clin Oncol. 2017 Oct;7(4):539-542. doi: 10.3892/mco.2017.1379. Epub 2017 Aug 
      18.