PMID- 2904760
OWN - NLM
STAT- MEDLINE
DCOM- 19890125
LR  - 20190626
IS  - 0002-9343 (Print)
IS  - 0002-9343 (Linking)
VI  - 85
IP  - 6A
DP  - 1988 Dec 23
TI  - Class II human leukocyte antigen genes and T cell receptor polymorphisms in 
      patients with rheumatoid arthritis.
PG  - 14-6
AB  - Human leukocyte antigen (HLA) typing was performed in 174 patients with 
      rheumatoid arthritis and 222 white control subjects. Increases in HLA-DR4 and 
      HLA-DR1 were observed as in previous studies. Each of these appeared to be 
      inherited as dominant risk factors. Southern blotting with a DR-beta probe after 
      digestion of genomic DNA with the restriction enzyme Bam HI showed seven bands. 
      Three of them correlated with DR4 and were increased in rheumatoid arthritis 
      patients. Subsets of DR4 were determined by polymerase chain reaction 
      amplification followed by hybridization with oligonucleotide probes. Dw4 was 
      increased in rheumatoid arthritis patients, and the frequency of the other 
      subsets appeared to be similar in rheumatoid arthritis patients and control 
      subjects. A polymorphism associated with the T cell receptor V-beta-8 gene family 
      was significantly increased in rheumatoid arthritis patients.
FAU - Gao, X J
AU  - Gao XJ
AD  - Department of Internal Medicine, University of Texas Southwestern Medical Center, 
      Dallas 75235.
FAU - Ball, E J
AU  - Ball EJ
FAU - Dombrausky, L
AU  - Dombrausky L
FAU - Olsen, N J
AU  - Olsen NJ
FAU - Pincus, T
AU  - Pincus T
FAU - Khan, M A
AU  - Khan MA
FAU - Wolfe, F
AU  - Wolfe F
FAU - Stastny, P
AU  - Stastny P
LA  - eng
GR  - 1-P50-AR39169-01/AR/NIAMS NIH HHS/United States
GR  - 5-P01-AI23271-03/AI/NIAID NIH HHS/United States
GR  - 5-R01-AI21278-05/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Med
JT  - The American journal of medicine
JID - 0267200
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-Dx antigen)
RN  - 0 (Oligonucleotide Probes)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - EC 3.1.21.- (Deoxyribonuclease BamHI)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - Deoxyribonuclease BamHI
MH  - HLA-D Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Nucleic Acid Hybridization
MH  - Oligonucleotide Probes
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Receptors, Antigen, T-Cell/*genetics
EDAT- 1988/12/23 00:00
MHDA- 1988/12/23 00:01
CRDT- 1988/12/23 00:00
PHST- 1988/12/23 00:00 [pubmed]
PHST- 1988/12/23 00:01 [medline]
PHST- 1988/12/23 00:00 [entrez]
AID - 0002-9343(88)90373-7 [pii]
AID - 10.1016/0002-9343(88)90373-7 [doi]
PST - ppublish
SO  - Am J Med. 1988 Dec 23;85(6A):14-6. doi: 10.1016/0002-9343(88)90373-7.