PMID- 29048792
OWN - NLM
STAT- MEDLINE
DCOM- 20181114
LR  - 20181114
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 35
IP  - 6
DP  - 2017 Jun 8
TI  - [A novel pattern for predicting the quality of Chinese herba preparation 
      intelligently by high performance liquid chromatographic formula fingerprints].
PG  - 643-649
LID - 10.3724/SP.J.1123.2016.12041 [doi]
AB  - In order to build the fusion models, the high performance liquid chromatographic 
      (HPLC) fingerprints of scutellariae radix (SR), rhei radix et rhizoma (RRR), 
      coptidis rhizoma (CR) and their synthesizing fingerprints were developed in this 
      study. After exploring the consistency between the fingerprints of compound 
      synthesizing fingerprints (CSF) and the sample, the quality of traditional 
      Chinese medicine preparation was predicted intelligently using CSF. HPLC coupled 
      with diode array detector was used to obtain chromatograms of SR, RRR, CR and Yi 
      Qing Tablet (YQT) samples at 268 nm. Meanwhile, the quality of CSF and the 15 
      batches of YQT samples was evaluated by systematically quantified fingerprint 
      method (SQFM) qualitatively and quantitatively. The chromatograms showed that CSF 
      covered the main fingerprints' information of each herb and the 55 common peaks 
      of CSF covered the main information of the 50 common peaks in YQT sample. The 
      evaluation results showed that among the 15 batches of YQT samples, only YQT-S01 
      was grade 5 and the others were all above grade 3. Most of the CSFs were grade 2 
      or grade 1 except CSF-2 which was grade 6. The fingerprints of Chinese herba 
      preparation could be replaced by CSF to achieve a novel pattern for predicting 
      the quality of TCM preparation intelligently by studying the relationship between 
      the standard fingerprints and the CSF, and simultaneously developing first-class 
      evaluation software.
FAU - Gong, Dandan
AU  - Gong D
AD  - College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Dong, Jiajun
AU  - Dong J
AD  - College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Sun, Guoxiang
AU  - Sun G
AD  - College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. 
      gxswmwys@163.com.
FAU - Zhang, Jing
AU  - Zhang J
AD  - College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Zhang, Yujing
AU  - Zhang Y
AD  - College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Sun, Wanyang
AU  - Sun W
AD  - Institute of Traditional Chinese Medicine & Natural Products, College of 
      Pharmacy, Jinan University, Guangzhou 510632, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Tablets)
SB  - IM
MH  - *Chromatography, High Pressure Liquid
MH  - Drugs, Chinese Herbal/*chemistry
MH  - Medicine, Chinese Traditional
MH  - Quality Control
MH  - Rhizome
MH  - Tablets
OTO - NOTNLM
OT  - compound synthesizing fingerprints (CSF)
OT  - high performance liquid chromatographic (HPLC)
OT  - intelligent prediction
OT  - quality control of traditional Chinese medicine (TCM)
EDAT- 2017/10/20 06:00
MHDA- 2018/11/15 06:00
CRDT- 2017/10/20 06:00
PHST- 2017/10/20 06:00 [entrez]
PHST- 2017/10/20 06:00 [pubmed]
PHST- 2018/11/15 06:00 [medline]
AID - 10.3724/SP.J.1123.2016.12041 [doi]
PST - ppublish
SO  - Se Pu. 2017 Jun 8;35(6):643-649. doi: 10.3724/SP.J.1123.2016.12041.