PMID- 29048813
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20181109
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 35
IP  - 8
DP  - 2017 Aug 8
TI  - [Determination of three tranquillizer residues in animal foods by QuEChERS-high 
      performance liquid chromatography-tandem mass spectrometry].
PG  - 801-807
LID - 10.3724/SP.J.1123.2017.03043 [doi]
AB  - A method for simultaneous determination of chlorpromazine, diazepam and 
      metolazone residues in porcine muscle, fish, liver and kidney was developed using 
      QuEChERS and HPLC-MS/MS technique. The samples were extracted with ethyl acetate 
      and cleaned up with C(18), N-propylethylendiamine (PSA) and NH(2) sorbents after 
      using Na(2)SO(4) as dehydrating agent. The analytes were separated by a special 
      C(18) column, Atlantis T3, and gradiently eluted with a mixed solution of 5 
      mmol/L formic acid and acetonitrile at a flow rate of 0.35 mL/min. The mass 
      spectrometric analysis that quantified using isotope internal standard, was 
      carried out with electrospray positive ion source (ESI(+)) and multiple reaction 
      monitoring mode (MRM). The linearity of the calibration curves was good in the 
      range of 0.2-5.0 mu g/L. The recoveries at three different spiked levels (0.5, 1 
      and 5 mu g/kg) in four matrices were in the range of 92.5%-117.8%. The 
      repeatability expressed as relative standard deviations (RSDs) ranged from 0.7% 
      to 11.6% (n=6). The method, with wide matrix range of application, is highly 
      effective and sensitive and suitable for the rapid analysis of large quantities 
      of samples.
FAU - Zou, You
AU  - Zou Y
AD  - Inspection and Quarantine Technology Center, Guangdong Entry-Exit Inspection and 
      Quarantine Bureau, Guangzhou 510623, China.
FAU - Shao, Linzhi
AU  - Shao L
AD  - Inspection and Quarantine Technology Center, Guangdong Entry-Exit Inspection and 
      Quarantine Bureau, Guangzhou 510623, China.
FAU - Chen, Simin
AU  - Chen S
AD  - Inspection and Quarantine Technology Center, Guangdong Entry-Exit Inspection and 
      Quarantine Bureau, Guangzhou 510623, China.
FAU - Ouyang, Shaolun
AU  - Ouyang S
AD  - Inspection and Quarantine Technology Center, Guangdong Entry-Exit Inspection and 
      Quarantine Bureau, Guangzhou 510623, China. oysl@iqtc.cn.
FAU - Lin, Feng
AU  - Lin F
AD  - Inspection and Quarantine Technology Center, Guangdong Entry-Exit Inspection and 
      Quarantine Bureau, Guangzhou 510623, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Tranquilizing Agents)
SB  - IM
MH  - *Animal Feed
MH  - Animals
MH  - *Chromatography, High Pressure Liquid
MH  - Fishes
MH  - Swine
MH  - *Tandem Mass Spectrometry
MH  - Tranquilizing Agents/*analysis
OTO - NOTNLM
OT  - QuEChERS
OT  - animal foods
OT  - high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
OT  - tranquillizers
EDAT- 2017/10/20 06:00
MHDA- 2018/11/10 06:00
CRDT- 2017/10/20 06:00
PHST- 2017/10/20 06:00 [entrez]
PHST- 2017/10/20 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.03043 [doi]
PST - ppublish
SO  - Se Pu. 2017 Aug 8;35(8):801-807. doi: 10.3724/SP.J.1123.2017.03043.