PMID- 29048815
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20181109
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 35
IP  - 8
DP  - 2017 Aug 8
TI  - [Simultaneous rapid determination of 81 glucocorticoids in cosmetics by 
      dispersive solid phase extraction and liquid chromatography-tandem mass 
      spectrometry].
PG  - 816-825
LID - 10.3724/SP.J.1123.2017.04005 [doi]
AB  - A novel method was developed for the simultaneous rapid determination of 81 
      illegally added glucocorticoids (GCs) in cosmetics using dispersive-solid phase 
      extraction (d-SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). 
      The analytes were extracted by acetonitrile after dispersing with water, and then 
      purified using the C(18) and primary secondary amine (PSA). The chromatographic 
      separations were performed on a Poroshell 120 PFP column (100 mmx2.1 mm, 2.7 mu m) 
      under multiple chromatographic retention modes. Acetonitrile and 0.2% (v/v) 
      acetic acid aqueous solution were used as mobile phases with gradient elution, 
      and all the 10 groups of isomers were baseline separated. The qualitative 
      identification and quantitative analysis of the 81 GCs were operated in the 
      electrospray ionization positive mode using dynamic multiple reaction monitoring 
      (DMRM). The 81 GCs finally were quantified by internal standard method. The 
      correlation coefficients of linear calibration curves were greater than 0.99 in 
      the corresponding mass concentration ranges. The average recoveries of the 81 GCs 
      at three spiked levels ranged from 68.8% to 105.3% with relative standard 
      deviations (RSDs) of 2.9%-13.1% (n=6). The LODs (S/N >/= 3) and LOQs (S/N >/= 10) 
      were 0.002-0.006 mu g/g and 0.005-0.020 mu g/g, respectively. A number of 137 
      cosmetic samples submitted by customers were screened. Sixteen positive samples 
      were found, and the contents of GCs were from 16.9 mu g/g to 158 mu g/g. The 
      results showed that the new method is simple, rapid, sensitive and reliable, and 
      it is suitable for qualitative and quantitative screening analysis of the 81 GCs 
      in cosmetics simultaneously.
FAU - Luo, Huitai
AU  - Luo H
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
FAU - Huang, Xiaolan
AU  - Huang X
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China. 
      wenhxl@126.com.
FAU - Wu, Huiqin
AU  - Wu H
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
FAU - Zhang, Qiuyan
AU  - Zhang Q
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
FAU - Zhu, Zhixin
AU  - Zhu Z
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
FAU - Huang, Fang
AU  - Huang F
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
FAU - Lin, Xiaoshan
AU  - Lin X
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
FAU - Ma, Yefen
AU  - Ma Y
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
FAU - Deng, Xin
AU  - Deng X
AD  - Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, 
      China National Analytical Center(Guangzhou), Guangzhou 510070, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Cosmetics)
RN  - 0 (Glucocorticoids)
SB  - IM
MH  - Chromatography, High Pressure Liquid
MH  - *Chromatography, Liquid
MH  - Cosmetics/*chemistry
MH  - Glucocorticoids/*analysis
MH  - Limit of Detection
MH  - Solid Phase Extraction
MH  - *Tandem Mass Spectrometry
OTO - NOTNLM
OT  - cosmetics
OT  - dispersive-solid phase extraction (d-SPE)
OT  - glucocorticoids (GCs)
OT  - illegally added
OT  - isotope dilution
OT  - liquid chromatography-tandem mass spectrometry (LC-MS/MS)
EDAT- 2017/10/20 06:00
MHDA- 2018/11/10 06:00
CRDT- 2017/10/20 06:00
PHST- 2017/10/20 06:00 [entrez]
PHST- 2017/10/20 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
AID - 10.3724/SP.J.1123.2017.04005 [doi]
PST - ppublish
SO  - Se Pu. 2017 Aug 8;35(8):816-825. doi: 10.3724/SP.J.1123.2017.04005.