PMID- 29049728
OWN - NLM
STAT- MEDLINE
DCOM- 20171027
LR  - 20181113
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Print)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 12
DP  - 2017 Oct 1
TI  - Surgically Induced Focal Retinal Detachment Does Not Cause Detectable SD-OCT 
      Retinal Changes in Normal Human Retina.
PG  - 5270-5279
LID - 10.1167/iovs.17-22737 [doi]
AB  - PURPOSE: Induction of focal retinal detachment (RD) for subretinal delivery of 
      stem cells and gene therapy is increasingly common. In order to determine if this 
      procedure has an adverse impact on the retina, we use spectral-domain optical 
      coherence tomography (SD-OCT) to evaluate the pre- and postoperative retinal 
      anatomy of the incidentally detached normal retina surrounding large submacular 
      hemorrhages (SMH) during surgical displacement procedures. METHODS: 
      Retrospective, observational study of human subjects with monocular SMH evaluated 
      before and after surgical displacement using clinical exam, fundus photography, 
      and SD-OCT. Manual measurements of the inner retinal thickness (IRT), outer 
      retinal thickness (ORT), and full retinal thickness (FRT) were made in regions 
      involving the SMH and surrounding normal retina. Comparison of retinal thickness 
      measurements was made using the Wilcoxon signed-rank test. RESULTS: Seven eyes 
      were included in this study. All eyes successfully underwent surgical 
      displacement of SMH. Visual acuity improved in 6/7 subjects and was unchanged in 
      the remaining subject. Incidental RD of the normal retinal regions surrounding 
      the SMH did not cause any significant change in IRT, ORT, or FRT that was 
      detectable by SD-OCT. In contrast, mean FRT overlying regions with SMH was 
      significantly greater before surgery compared to after displacement of SMH or 
      normal adjacent retina. CONCLUSIONS: Surgically induced focal RD does not cause 
      detectable retinal changes in the incidentally detached normal retina surrounding 
      large SMH. Therefore, surgical induction of focal RD should not be considered to 
      have the same adverse impact on the retina as pathologic RD.
FAU - Kogachi, Kaitlin
AU  - Kogachi K
AD  - USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, 
      United States.
FAU - Wolfe, Jeremy D
AU  - Wolfe JD
AD  - Associated Retinal Consultants, Oakland University William Beaumont School of 
      Medicine, Royal Oak, Michigan, United States.
FAU - Kashani, Amir H
AU  - Kashani AH
AD  - USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, 
      United States.
LA  - eng
GR  - K08 EY027006/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/diagnostic imaging/*pathology
MH  - Retinal Detachment/physiopathology/*surgery
MH  - Retinal Hemorrhage/physiopathology/*surgery
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
MH  - Vitrectomy
PMC - PMC5644709
EDAT- 2017/10/20 06:00
MHDA- 2017/10/28 06:00
PMCR- 2017/10/01
CRDT- 2017/10/20 06:00
PHST- 2017/10/20 06:00 [entrez]
PHST- 2017/10/20 06:00 [pubmed]
PHST- 2017/10/28 06:00 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
AID - 2657756 [pii]
AID - IOVS-17-22737 [pii]
AID - 10.1167/iovs.17-22737 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5270-5279. doi: 
      10.1167/iovs.17-22737.