PMID- 29049811 OWN - NLM STAT- MEDLINE DCOM- 20190109 LR - 20190109 IS - 1569-9285 (Electronic) IS - 1569-9285 (Linking) VI - 26 IP - 2 DP - 2018 Feb 1 TI - Effect of cone reconstruction on right ventricular function in patients with Ebstein's anomaly: a meta-analysis. PG - 301-306 LID - 10.1093/icvts/ivx312 [doi] AB - OBJECTIVES: Cone reconstruction (CR) is a novel technique for surgically treating the tricuspid valve and right ventricle (RV) in patients with Ebstein's anomaly. However, precise changes in the RV function after CR remain unclear. This study aimed to evaluate the RV size and New York Heart Association (NYHA) functional class by conducting a meta-analysis of reported data. METHODS: The MEDLINE, EMBASE, Cochrane Library and China National Knowledge Infrastructure databases were searched for relevant studies. The variables were RV measurements, NYHA functional classes and tricuspid valve regurgitation grades. A fixed/random effects model was used to summarize the estimates of mean difference with standard error. Sensitivity analysis was conducted to ascertain the primary origin of the heterogeneity. RESULTS: Nine studies that involved 210 patients were included. The results demonstrated that after CR, the functional RV volume significantly decreased, NYHA functional class improved and tricuspid valve regurgitation grade decreased. CONCLUSIONS: Thus, CR appeared to be a positive approach for Ebstein's anomaly, with good results being obtained for the RV size and NYHA functional class. Because some limitations could not be overcome, studies with more data on RV and longer follow-ups are required to confirm our study results. CI - (c) The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. FAU - Li, Dongxu AU - Li D AD - Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Sichuan, China. AD - Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan. FAU - Hirata, Yasutaka AU - Hirata Y AD - Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan. FAU - Zhou, Xu AU - Zhou X AD - Evidence-Based Medicine Research Center, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Jiangxi, China. FAU - Masuzawa, Akihiro AU - Masuzawa A AD - Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan. FAU - Ono, Minoru AU - Ono M AD - Department of Cardiac Surgery, The University of Tokyo, Tokyo, Japan. FAU - An, Qi AU - An Q AD - Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Sichuan, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review PL - England TA - Interact Cardiovasc Thorac Surg JT - Interactive cardiovascular and thoracic surgery JID - 101158399 SB - IM MH - Cardiac Surgical Procedures/*methods MH - Ebstein Anomaly/*diagnosis/physiopathology/surgery MH - Echocardiography MH - Heart Ventricles/diagnostic imaging/*physiopathology MH - Humans MH - Tricuspid Valve/diagnostic imaging/*surgery MH - Tricuspid Valve Insufficiency/diagnosis/physiopathology/*surgery MH - Ventricular Function, Right/*physiology MH - *Ventricular Remodeling OTO - NOTNLM OT - Cone reconstruction OT - Ebstein's anomaly OT - Meta-analysis OT - New York Heart Association functional class OT - Right ventricle OT - Tricuspid valve EDAT- 2017/10/20 06:00 MHDA- 2019/01/10 06:00 CRDT- 2017/10/20 06:00 PHST- 2017/05/11 00:00 [received] PHST- 2017/08/13 00:00 [accepted] PHST- 2017/10/20 06:00 [pubmed] PHST- 2019/01/10 06:00 [medline] PHST- 2017/10/20 06:00 [entrez] AID - 4210473 [pii] AID - 10.1093/icvts/ivx312 [doi] PST - ppublish SO - Interact Cardiovasc Thorac Surg. 2018 Feb 1;26(2):301-306. doi: 10.1093/icvts/ivx312.