PMID- 29050222
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 41
DP  - 2017 Sep 19
TI  - Beneficial effect of fluoxetine treatment aganist psychological stress is 
      mediated by increasing BDNF expression in selected brain areas.
PG  - 69527-69537
LID - 10.18632/oncotarget.17891 [doi]
AB  - SSRI antidepressant fluoxetine is widely used to treat psychological stress 
      related disorders, however the underlying working mechanisms is not fully 
      understood, as SSRIs can rapidly increase the extracellular serotonin levels but 
      it normally takes weeks to reveal their therapeutic effect in the stress-related 
      psychological disorders. Our previous study demonstrated that purely 
      psychological stress without any physic stimuli induces a biphasic change in the 
      expression of brain-derived neurotrophic factor (BDNF), which immediately 
      decrease and then gradually increase after the stress; and that the latter BDNF 
      increase in response to the psychological stress involves the activation of 
      serotonin system. To investigate the role of BDNF in the fluoxetine treatment for 
      stress-related psychological disorders, we examined the mRNA and protein levels 
      of BDNF in the brain of Sprague-Dawley (SD) rats, which were pretreated with 
      fluoxetine at 10 mg/kg or vehicle solution for 14 days, over 24 hour after an 
      acute psychological stress exposure. In situ hybridization and 
      immunohistochemistry were performed to detect the expression of BDNF at different 
      time points in various brain regions after the psychological stress. We found 
      that fluoxetine treatment completely blocked the BDNF decrease induced by the 
      psychological stress, and also enhanced the gradual increase in the expression of 
      BDNF in most of the brain regions except VTA after the psychological stress. The 
      results suggest that the enhancement in BDNF levels induced by chronic fluoxetine 
      treatment mediates the therapeutic effect against psychological stress.
FAU - Li, Gongying
AU  - Li G
AD  - Insitute of Mental health, Jining Medical University, Jining, 272067, China.
FAU - Jing, Ping
AU  - Jing P
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, 325000, China.
FAU - Liu, Zhidong
AU  - Liu Z
AD  - Tianjin Fourth Central Hospital of Tianjin Medical University, Tianjin, 300000, 
      China.
FAU - Li, Zhiruo
AU  - Li Z
AD  - Department of Neurology, The Affiliated Hospital of Jining Medical University, 
      Jining, 272000, China.
FAU - Ma, Hongxia
AU  - Ma H
AD  - Department of Psychiatry, The Second Affiliated Hospital of Jining Medical 
      University, Jining, 272051, China.
FAU - Tu, Wenzhen
AU  - Tu W
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, 325000, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, 325000, China.
FAU - Zhuo, Chuanjun
AU  - Zhuo C
AD  - Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, Zhejiang 
      Province, 325000, China.
AD  - Insitute of Mental health, Jining Medical University, Jining, 272067, China.
AD  - Department of Psychiatric Neuroimaging Laboratory, Tianjin Anding Hospital, 
      Tianjin Mental Health Center, Tianjin 300222, China.
AD  - Department of Psychiatry, Tianjin Anning Hospital, Tianjin 300300, China.
LA  - eng
PT  - Journal Article
DEP - 20170515
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5642497
OTO - NOTNLM
OT  - brain-derived neurotrophic factor (BDNF)
OT  - fluoxetine
OT  - psychological stress
OT  - serotonin
COIS- CONFLICTS OF INTEREST The authors report no conflicts of interest.
EDAT- 2017/10/21 06:00
MHDA- 2017/10/21 06:01
PMCR- 2017/09/19
CRDT- 2017/10/21 06:00
PHST- 2017/01/23 00:00 [received]
PHST- 2017/04/29 00:00 [accepted]
PHST- 2017/10/21 06:00 [entrez]
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2017/10/21 06:01 [medline]
PHST- 2017/09/19 00:00 [pmc-release]
AID - 17891 [pii]
AID - 10.18632/oncotarget.17891 [doi]
PST - epublish
SO  - Oncotarget. 2017 May 15;8(41):69527-69537. doi: 10.18632/oncotarget.17891. 
      eCollection 2017 Sep 19.