PMID- 29050585
OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR  - 20181202
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 178
DP  - 2017 Dec 15
TI  - Non-cytotoxic hybrid bioscaffolds of chitosan-silica: Sol-gel synthesis, 
      characterization and proposed application.
PG  - 190-199
LID - S0144-8617(17)31072-X [pii]
LID - 10.1016/j.carbpol.2017.09.047 [doi]
AB  - Biohybrid chitosan-silica scaffolds were synthesized through the sol-gel and the 
      freeze drying processes. Hydrolysis and condensation of chitosan with 
      tetraethylorthosilicate (TEOS) in the presence of 3-isocyanatopropyl 
      triethoxysilane (ICPTES) were successfully carried out. Results obtained from 
      FTIR, swelling test and pyrolysis confirmed that the hybrid scaffolds containing 
      covalent coupling between the organic and inorganic networks were formed with 
      high crosslink density of SiOSi bridging and could be classified as the class II 
      material. The hybridization also resulted in improvements on mechanical strength 
      and stability comparing to the pure chitosan. In vitro investigations on the 
      guided bone regeneration and the cytotoxicity were also performed. SEM-EDS was 
      used to examine the proliferation of calcium phosphate mineral at the scaffold 
      surface after an immersion in simulated body fluid. The results revealed that the 
      hybrid scaffolds exhibited a rapid induction of calcium phosphate mineral without 
      cytotoxicity effect, reflecting an excellent in vitro bone bioactivity which was 
      superior to the pure chitosan scaffold.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Pipattanawarothai, Athit
AU  - Pipattanawarothai A
AD  - Department of Chemistry and Center of Excellence for Innovation in Chemistry, 
      Faculty of Science, Burapha University, Chonburi 20131, Thailand. Electronic 
      address: atith.m@hotmail.com.
FAU - Suksai, Chomchai
AU  - Suksai C
AD  - Department of Chemistry and Center of Excellence for Innovation in Chemistry, 
      Faculty of Science, Burapha University, Chonburi 20131, Thailand. Electronic 
      address: jomjai@buu.ac.th.
FAU - Srisook, Klaokwan
AU  - Srisook K
AD  - Department of Biochemistry and Center of Excellence for Innovation in Chemistry, 
      Faculty of Science, Burapha University, Chonburi 20131, Thailand. Electronic 
      address: klaokwan@buu.ac.th.
FAU - Trakulsujaritchok, Thanida
AU  - Trakulsujaritchok T
AD  - Department of Chemistry and Center of Excellence for Innovation in Chemistry, 
      Faculty of Science, Burapha University, Chonburi 20131, Thailand. Electronic 
      address: thanida@buu.ac.th.
LA  - eng
PT  - Journal Article
DEP - 20170914
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Biocompatible Materials)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/chemistry
MH  - *Bone Regeneration
MH  - Chitosan/*chemistry
MH  - Human Umbilical Vein Endothelial Cells
MH  - Humans
MH  - Mice
MH  - Porosity
MH  - RAW 264.7 Cells
MH  - Silicon Dioxide/*chemistry
MH  - *Tissue Scaffolds
OTO - NOTNLM
OT  - Bioscaffold
OT  - Bone regeneration
OT  - Chitosan
OT  - Cytotoxicity
OT  - Hybrid
OT  - Sol-gel
EDAT- 2017/10/21 06:00
MHDA- 2018/07/26 06:00
CRDT- 2017/10/21 06:00
PHST- 2017/06/17 00:00 [received]
PHST- 2017/08/31 00:00 [revised]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2017/10/21 06:00 [entrez]
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
AID - S0144-8617(17)31072-X [pii]
AID - 10.1016/j.carbpol.2017.09.047 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2017 Dec 15;178:190-199. doi: 10.1016/j.carbpol.2017.09.047. 
      Epub 2017 Sep 14.