PMID- 29050620
OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR  - 20181202
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 178
DP  - 2017 Dec 15
TI  - Safe therapeutics of murine melanoma model using a novel antineoplasic, the 
      partially methylated mannogalactan from Pleurotus eryngii.
PG  - 95-104
LID - S0144-8617(17)31001-9 [pii]
LID - 10.1016/j.carbpol.2017.08.117 [doi]
AB  - A heteropolysaccharide was isolated by cold aqueous extraction from edible 
      mushroom Pleurotus eryngii ("King Oyster") basidiocarps and its biological 
      properties were evaluated. Structural assignments were carried out using mono- 
      and bidimensional NMR spectroscopy, monosaccharide composition, and methylation 
      analyses. A mannogalactan having a main chain of (1-->6)-linked 
      alpha-d-galactopyranosyl and 3-O-methyl-alpha-d-galactopyranosyl residues, both partially 
      substituted at OH-2 by beta-d-Manp (MG-Pe) single-unit was found. Biological effects 
      of mannogalactan from P. eryngii (MG-Pe) were tested against murine melanoma 
      cells. MG-Pe was non-cytotoxic, but reduced in vitro melanoma cells invasion. 
      Also, 50mg/kg MG-Pe administration to melanoma-bearing C57BL/6 mice up to 10days 
      decreased in 60% the tumor volume compared to control. Additionally, no changes 
      were observed when biochemical profile, complete blood cells count (CBC), organs, 
      and body weight were analyzed. Mg-Pe was shown to be a promising anti-melanoma 
      molecule capable of switching melanoma cells to a non-invasive phenotype with no 
      toxicity to melanoma-bearing mice.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Biscaia, S M P
AU  - Biscaia SMP
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil.
FAU - Carbonero, E R
AU  - Carbonero ER
AD  - Departamento de Bioquimica, Universidade Federal de Goias, CEP 75704-020, 
      Catalao, Goias, Brazil.
FAU - Bellan, D L
AU  - Bellan DL
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil.
FAU - Borges, B S
AU  - Borges BS
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil.
FAU - Costa, C R
AU  - Costa CR
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil.
FAU - Rossi, G R
AU  - Rossi GR
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil.
FAU - Goncalves, J P
AU  - Goncalves JP
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil.
FAU - Melo, C M
AU  - Melo CM
AD  - Centro de Investigacao Translacional em Oncologia (CTO), Instituto do Cancer do 
      Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo 
      (USP), CEP 01246903, Sao Paulo, Sao Paulo, Brazil.
FAU - Livero, F A R
AU  - Livero FAR
AD  - Departamento de Farmacologia, UFPR, CEP 81531-980, Curitiba, Parana, Brazil.
FAU - Ruthes, A C
AU  - Ruthes AC
AD  - Division of Glycoscience, AlbaNova University Centre, Royal Institute of 
      Technology, 106 91 Stockholm, Sweden.
FAU - Zotz, R
AU  - Zotz R
AD  - Pontificia Universidade Catolica do Parana, Animal Facility, CEP 80215-901, 
      Curitiba, Parana, Brazil.
FAU - Silva, E V
AU  - Silva EV
AD  - Departamento de Bioquimica, Universidade Federal de Goias, CEP 75704-020, 
      Catalao, Goias, Brazil.
FAU - Oliveira, C C
AU  - Oliveira CC
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil.
FAU - Acco, A
AU  - Acco A
AD  - Departamento de Farmacologia, UFPR, CEP 81531-980, Curitiba, Parana, Brazil.
FAU - Nader, H B
AU  - Nader HB
AD  - Departamento de Bioquimica, Universidade Federal de Sao Paulo, CEP 04044-020 Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Chammas, R
AU  - Chammas R
AD  - Centro de Investigacao Translacional em Oncologia (CTO), Instituto do Cancer do 
      Estado de Sao Paulo (ICESP), Faculdade de Medicina, Universidade de Sao Paulo 
      (USP), CEP 01246903, Sao Paulo, Sao Paulo, Brazil.
FAU - Iacomini, M
AU  - Iacomini M
AD  - Departamento de Bioquimica e Biologia Molecular, UFPR, CEP 81531-980, Curitiba, 
      Parana, Brazil.
FAU - Franco, C R C
AU  - Franco CRC
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil. Electronic address: crcfranc@terra.com.br.
FAU - Trindade, E S
AU  - Trindade ES
AD  - Departamento de Biologia Celular, Universidade Federal do Parana (UFPR), CEP 
      81351-980, Curitiba, Parana, Brazil. Electronic address: edstrindad@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20170906
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Fungal Polysaccharides)
RN  - 0 (Galactans)
SB  - IM
MH  - Animals
MH  - Fruiting Bodies, Fungal/chemistry
MH  - Fungal Polysaccharides/*pharmacology
MH  - Galactans/*pharmacology
MH  - Magnetic Resonance Spectroscopy
MH  - Melanoma/*drug therapy
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pleurotus/*chemistry
OTO - NOTNLM
OT  - Antitumor
OT  - Chemical structure
OT  - Mannogalactan
OT  - Melanoma B16-F10
OT  - Non-cytotoxic
OT  - Pleurotus eryngii ("King Oyster")
EDAT- 2017/10/21 06:00
MHDA- 2018/07/26 06:00
CRDT- 2017/10/21 06:00
PHST- 2017/05/02 00:00 [received]
PHST- 2017/08/22 00:00 [revised]
PHST- 2017/08/27 00:00 [accepted]
PHST- 2017/10/21 06:00 [entrez]
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
AID - S0144-8617(17)31001-9 [pii]
AID - 10.1016/j.carbpol.2017.08.117 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2017 Dec 15;178:95-104. doi: 10.1016/j.carbpol.2017.08.117. Epub 
      2017 Sep 6.