PMID- 29050702
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20221207
IS  - 2530-0172 (Electronic)
IS  - 2530-0164 (Linking)
VI  - 64
IP  - 9
DP  - 2017 Nov
TI  - Relationship between a fragmented QRS and microalbuminuria in patients with type 
      2 diabetes mellitus.
PG  - 464-470
LID - S2530-0164(17)30190-8 [pii]
LID - 10.1016/j.endinu.2017.07.004 [doi]
AB  - INTRODUCTION: Microalbuminuria (MAU), a complication of diabetes, is closely 
      related to cardiovascular events. A fragmented QRS (fQRS) in the 
      electrocardiogram (ECG) was found to be strongly associated to cardiovascular 
      morbidity and mortality. OBJECTIVE: The aim of this study was to assess the 
      association between a fQRS and MAU in patients with type 2 diabetes mellitus 
      (T2DM). PATIENTS AND METHODS: One hundred and twenty-seven patients (mean age, 
      50.49 years; 44.01% male) with T2DM of at least six months duration and at least 
      two urine albumin/creatinine ratios (ACRs) available were enrolled into the study 
      between December 2015 and May 2016. All patients underwent ECG and 
      echocardiography, and were taken blood and urine samples. Patients were divided 
      into two groups according to presence of fQRS (group 1) or absence of fQRS (group 
      2). RESULTS: Both groups had similar baseline characteristics. MAU and 
      glycosylated hemoglobin (HbA1c) levels and left ventricular end-diastolic 
      diameter (LVEDd) were increased in patients with a fQRS in the ECG (p=0.002, 
      p=0.02, and p=0.007, respectively). Univariate and multivariate logistic 
      regression analysis showed MAU and an increased LVEDd to be independent risk 
      factors for the presence of a fQRS in the ECG of T2DM patients. DISCUSSION AND 
      CONCLUSIONS: In this study, a fQRS was associated to MAU. In T2DM, MAU may be 
      related to subclinical diastolic and systolic dysfunction.
CI  - Copyright (c) 2017. Publicado por Elsevier Espana, S.L.U.
FAU - Cetin, Sukru
AU  - Cetin S
AD  - Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, 
      Istanbul, Turkey. Electronic address: chetinsukru@hotmail.com.
FAU - Yildiz, Suleyman Sezai
AU  - Yildiz SS
AD  - Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Mazi, Emrah Erkan
AU  - Mazi EE
AD  - Department of Internal Medicine, Sisli Hamidiye Etfal Training and Research 
      Hospital, Istanbul, Turkey.
FAU - Keskin, Kudret
AU  - Keskin K
AD  - Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Cetinkal, Gokhan
AU  - Cetinkal G
AD  - Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Gurdal, Ahmet
AU  - Gurdal A
AD  - Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Karabay, Umut
AU  - Karabay U
AD  - Department of Internal Medicine, Sisli Hamidiye Etfal Training and Research 
      Hospital, Istanbul, Turkey.
FAU - Orta Kilickesmez, Kadriye
AU  - Orta Kilickesmez K
AD  - Department of Cardiology, Sisli Hamidiye Etfal Training and Research Hospital, 
      Istanbul, Turkey.
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20170901
PL  - Spain
TA  - Endocrinol Diabetes Nutr
JT  - Endocrinologia, diabetes y nutricion
JID - 101698946
RN  - 0 (Cations)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Albuminuria/*etiology
MH  - Cations/blood
MH  - Creatinine/blood/urine
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*physiopathology/urine
MH  - Diabetic Cardiomyopathies/diagnostic imaging/mortality/*physiopathology
MH  - Diabetic Nephropathies/*urine
MH  - Echocardiography
MH  - *Electrocardiography
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Hypertrophy, Left Ventricular/diagnostic imaging/etiology/physiopathology
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Prospective Studies
OTO - NOTNLM
OT  - Diabetes mellitus tipo 2
OT  - Fragmented QRS
OT  - Microalbuminuria
OT  - QRS fragmentado
OT  - Type 2 diabetes mellitus
EDAT- 2017/10/21 06:00
MHDA- 2018/11/27 06:00
CRDT- 2017/10/21 06:00
PHST- 2017/03/10 00:00 [received]
PHST- 2017/06/20 00:00 [revised]
PHST- 2017/07/01 00:00 [accepted]
PHST- 2017/10/21 06:00 [entrez]
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
AID - S2530-0164(17)30190-8 [pii]
AID - 10.1016/j.endinu.2017.07.004 [doi]
PST - ppublish
SO  - Endocrinol Diabetes Nutr. 2017 Nov;64(9):464-470. doi: 
      10.1016/j.endinu.2017.07.004. Epub 2017 Sep 1.