PMID- 29052236
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20180917
IS  - 1540-8159 (Electronic)
IS  - 0147-8389 (Linking)
VI  - 40
IP  - 12
DP  - 2017 Dec
TI  - Heart failure severity, inappropriate ICD therapy, and novel ICD programming: a 
      MADIT-RIT substudy.
PG  - 1405-1411
LID - 10.1111/pace.13216 [doi]
AB  - BACKGROUND: The effects of heart failure (HF) severity on risk of inappropriate 
      implantable cardioverter-defibrillator (ICD) therapy have not been thoroughly 
      investigated. We aimed to study the association between HF severity and 
      inappropriate ICD therapy in MADIT-RIT. METHODS: MADIT-RIT randomized 1,500 
      patients to three ICD programming arms: conventional (Arm A), high-rate cut-off 
      (Arm B: >/=200 beats/min), and delayed therapy (Arm C: 60-second delay for 
      >/=170 beats/min). We evaluated the association between New York Heart Association 
      (NYHA) class III (n = 256) versus class I-II (n = 251) and inappropriate ICD 
      therapy in Arm A patients with ICD-only and cardiac resynchronization therapy 
      with defibrillator (CRT-D). We additionally assessed benefit of novel ICD 
      programming in Arms B and C versus Arm A by NYHA classification. RESULTS: In Arm 
      A, the risk of inappropriate therapy was significantly higher in those with NYHA 
      III versus NYHA I-II for both ICD (hazard ratio [HR] = 2.55, confidence interval 
      [CI]: 1.51-4.30, P < 0.001) and CRT-D patients (HR = 3.73, CI: 1.14-12.23, 
      P = 0.030). This was consistent for inappropriate ATP and inappropriate ICD 
      therapy < 200 beats/min, but not for inappropriate shocks. Novel ICD programming 
      significantly reduced inappropriate therapy in patients with both NYHA III (Arm B 
      vs Arm A: HR = 0.08, P < 0.001; Arm C vs Arm A: HR = 0.17, P < 0.001) and NYHA 
      I-II (Arm B vs Arm A: HR = 0.25, P < 0.001; Arm C vs Arm A: HR = 0.28, 
      P < 0.001). CONCLUSION: Patients with more severe HF are at increased risk for 
      inappropriate ICD therapy, particularly ATP due to arrhythmias < 200 beats/min. 
      Novel programming with high-rate cut-off or delayed detection reduces 
      inappropriate ICD therapies in both mild and moderate HF.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Daimee, Usama A
AU  - Daimee UA
AUID- ORCID: 0000-0002-2839-5564
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
FAU - Vermilye, Katherine
AU  - Vermilye K
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
FAU - Rosero, Spencer
AU  - Rosero S
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
FAU - Schuger, Claudio D
AU  - Schuger CD
AD  - Division of Cardiology, Henry Ford Hospital, Detroit, MI, USA.
FAU - Daubert, James P
AU  - Daubert JP
AD  - Cardiology Division, Duke University Medical Center, Durham, NC, USA.
FAU - Zareba, Wojciech
AU  - Zareba W
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
FAU - McNitt, Scott
AU  - McNitt S
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
FAU - Polonsky, Bronislava
AU  - Polonsky B
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
FAU - Moss, Arthur J
AU  - Moss AJ
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
FAU - Kutyifa, Valentina
AU  - Kutyifa V
AD  - Heart Research Follow-Up Program, University of Rochester Medical Center, 
      Rochester, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20171122
PL  - United States
TA  - Pacing Clin Electrophysiol
JT  - Pacing and clinical electrophysiology : PACE
JID - 7803944
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - *Defibrillators, Implantable
MH  - Female
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Male
MH  - Medical Overuse
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
MH  - Retrospective Studies
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - HF severity
OT  - inappropriate ICD therapy
OT  - novel ICD programming
EDAT- 2017/10/21 06:00
MHDA- 2018/09/18 06:00
CRDT- 2017/10/21 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/08/13 00:00 [revised]
PHST- 2017/08/28 00:00 [accepted]
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2017/10/21 06:00 [entrez]
AID - 10.1111/pace.13216 [doi]
PST - ppublish
SO  - Pacing Clin Electrophysiol. 2017 Dec;40(12):1405-1411. doi: 10.1111/pace.13216. 
      Epub 2017 Nov 22.