PMID- 29053704
OWN - NLM
STAT- MEDLINE
DCOM- 20190208
LR  - 20190215
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 83
IP  - 2
DP  - 2018 Feb
TI  - Hypoxic renal injury in newborns with abdominal compartment syndrome (clinical 
      and experimental study).
PG  - 520-526
LID - 10.1038/pr.2017.263 [doi]
AB  - BackgroundSurgical treatment for gastroschisis and congenital diaphragmatic 
      hernia (CDH) commonly leads to abdominal compartment syndrome (ACS) associated 
      with hypoxic renal injury. We hypothesized that measurement of urinary and serum 
      concentrations of vascular endothelial growth factor (VEGF), pi-glutathione 
      S-transferase (pi-GST), and monocyte chemoattractant protein-1 (MCP-1) may serve 
      for noninvasive detection of hypoxic renal injury in such 
      patients.MethodsIntra-abdominal pressure (IAP), renal excretory function, and the 
      biomarker levels were analyzed before, 4, and 10 days after surgery. Association 
      between the biomarker levels and renal histology was investigated using an 
      original model of ACS in newborn rats.ResultsFour days after surgery, IAP 
      increased, renal excretory function decreased, and the levels of VEGF, pi-GST, and 
      MCP-1 increased, indicating renal injury. Ten days after surgery, IAP partially 
      decreased, renal excretory function completely restored, but the biomarker levels 
      remained elevated, suggesting the ongoing kidney injury. In the model of ACS, 
      increase in the biomarker levels was associated with progressing kidney 
      morphological alteration.ConclusionSurgical treatment for gastroschisis and CDH 
      is associated with prolonged hypoxic kidney injury despite complete restoration 
      of renal excretory function. Follow-up measurement of VEGF, pi-GST, and MCP-1 
      levels may provide a better tool for noninvasive assessment of renal parenchyma 
      in newborns with ACS.
FAU - Morozov, Dmitry
AU  - Morozov D
AD  - Department of Pediatric Surgery, Sechenov First Moscow State Medical University, 
      Moscow, Russia.
FAU - Morozova, Olga
AU  - Morozova O
AD  - Department of Pathophysiology, Sechenov First Moscow State Medical University, 
      Moscow, Russia.
FAU - Pervouchine, Dmitri
AU  - Pervouchine D
AD  - Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of 
      Science and Technology, Moscow, Russia.
FAU - Severgina, Lubov
AU  - Severgina L
AD  - Department of Pathological Anatomy, Sechenov First Moscow State Medical 
      University, Moscow, Russia.
FAU - Tsyplakov, Alexei
AU  - Tsyplakov A
AD  - Research Institute for Fundamental and Clinical Uronephrology, Saratov State 
      Medical University n. a. V. I. Razumovsky, Saratov, Russia.
FAU - Zakharova, Natalya
AU  - Zakharova N
AD  - Research Institute for Fundamental and Clinical Uronephrology, Saratov State 
      Medical University n. a. V. I. Razumovsky, Saratov, Russia.
FAU - Sushentsev, Nikita
AU  - Sushentsev N
AD  - Department of Pathophysiology, Sechenov First Moscow State Medical University, 
      Moscow, Russia.
FAU - Maltseva, Larisa
AU  - Maltseva L
AD  - Department of Pathophysiology, Sechenov First Moscow State Medical University, 
      Moscow, Russia.
FAU - Budnik, Ivan
AU  - Budnik I
AD  - Department of Pathophysiology, Sechenov First Moscow State Medical University, 
      Moscow, Russia.
LA  - eng
PT  - Journal Article
DEP - 20171115
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.5.1.18 (Glutathione Transferase)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Biomarkers/metabolism
MH  - Chemokine CCL2/metabolism
MH  - Compartment Syndromes/complications/*pathology
MH  - Congenital Abnormalities/*surgery
MH  - Disease Models, Animal
MH  - Female
MH  - Gastroschisis/metabolism/*surgery
MH  - Glutathione Transferase/metabolism
MH  - Hernia, Diaphragmatic/surgery
MH  - Hernias, Diaphragmatic, Congenital/*surgery
MH  - Humans
MH  - Hypoxia/physiopathology
MH  - Infant, Newborn
MH  - Intra-Abdominal Hypertension
MH  - Kidney/pathology
MH  - Male
MH  - Pressure
MH  - Prospective Studies
MH  - Rats
MH  - Rats, Wistar
MH  - Vascular Endothelial Growth Factor A/metabolism
EDAT- 2017/10/21 06:00
MHDA- 2019/02/09 06:00
CRDT- 2017/10/21 06:00
PHST- 2017/03/28 00:00 [received]
PHST- 2017/09/29 00:00 [accepted]
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2019/02/09 06:00 [medline]
PHST- 2017/10/21 06:00 [entrez]
AID - pr2017263 [pii]
AID - 10.1038/pr.2017.263 [doi]
PST - ppublish
SO  - Pediatr Res. 2018 Feb;83(2):520-526. doi: 10.1038/pr.2017.263. Epub 2017 Nov 15.