PMID- 29053933
OWN - NLM
STAT- MEDLINE
DCOM- 20180831
LR  - 20180831
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 43
IP  - 3
DP  - 2018 Mar
TI  - Chronic administration of ellagic acid improved the cognition in middle-aged 
      overweight men.
PG  - 266-273
LID - 10.1139/apnm-2017-0583 [doi]
AB  - This study aimed to investigate if ellagic acid has beneficial effects on 
      cognitive deficits in middle-aged overweight individuals and to propose a 
      possible mechanism. A total of 150 middle-aged male participants, including 76 
      normal-weight and 74 overweight men, aged between 45 to 55 years, were recruited 
      for this study. Both normal-weight and overweight participants were administered 
      either 50 mg ellagic acid or placebo cellulose daily for 12 weeks. Blood lipids, 
      peripheral brain-derived neurotrophic factor (BDNF), and saliva cortisol were 
      assessed on the last day of the procedure to investigate the effects induced by 
      ellagic acid. The results revealed that ellagic acid treatment improved the 
      levels of blood lipid metabolism with a 4.7% decline in total cholesterol, 7.3% 
      decline in triglycerides, 26.5% increase in high-density lipoprotein, and 6.5% 
      decline in low-density lipoprotein. Additionally, ellagic acid increased plasma 
      BDNF by 21.2% in the overweight group and showed no effects on normal-weight 
      participants. Moreover, the increased saliva cortisol level in overweight 
      individuals was inhibited by 22.7% in a 12-week ellagic acid treatment. Also, 
      compared with placebo, overweight individuals who consumed ellagic acid showed 
      enhanced cognitive function as measured by the Wechsler Adult Intelligence 
      Scale-Revised and the Montreal Cognitive Assessment. To the best of our 
      knowledge, this is the first report showing that ellagic acid prevents cognitive 
      deficits through normalization of lipid metabolism, increase in plasma BDNF 
      level, and reduction of saliva cortisol concentration. These results indicate 
      that ellagic acid has a potential to restore cognitive performance related to 
      mild age-related declines.
FAU - Liu, Ying
AU  - Liu Y
AD  - a Beijing Key Lab of Chinese Materia Medica Quality Evaluation, School of Chinese 
      Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, PR China.
FAU - Yu, Shuyi
AU  - Yu S
AD  - b College of Pharmacy & Center on Translational Neuroscience, Minzu University of 
      China, Beijing 100081, PR China.
FAU - Wang, Fen
AU  - Wang F
AD  - c Heilongjiang Nursing College, Heilongjiang, 150086, PR China.
FAU - Yu, Haitao
AU  - Yu H
AD  - d Qiqihar Medical University, Qiqihar 161006, PR China.
FAU - Li, Xueli
AU  - Li X
AD  - e Experimental Research Center, China Academy of Traditional Chinese Medicine, 
      Beijing, 100700, PR China.
FAU - Dong, Wanru
AU  - Dong W
AD  - f Heilongjiang University of Chinese Medicine, Heilongjiang, 150040, PR China.
FAU - Lin, Ruichao
AU  - Lin R
AD  - a Beijing Key Lab of Chinese Materia Medica Quality Evaluation, School of Chinese 
      Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, PR China.
FAU - Liu, Qingshan
AU  - Liu Q
AD  - b College of Pharmacy & Center on Translational Neuroscience, Minzu University of 
      China, Beijing 100081, PR China.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20171020
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 19YRN3ZS9P (Ellagic Acid)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Cognition/*drug effects
MH  - Double-Blind Method
MH  - Ellagic Acid/*pharmacology
MH  - Humans
MH  - Hydrocortisone/chemistry
MH  - Male
MH  - Middle Aged
MH  - *Overweight
MH  - Saliva/chemistry
OTO - NOTNLM
OT  - acide ellagique
OT  - brain-derived neurotrophic factor (BDNF)
OT  - cholesterol
OT  - cholesterol
OT  - cognition
OT  - cortisol
OT  - ellagic acid
OT  - facteur neutrophique derive du cerveau (BDNF)
OT  - lipoprotein
OT  - lipoproteines
OT  - midlife overweight
OT  - surpoids au mi-temps de la vie
EDAT- 2017/10/21 06:00
MHDA- 2018/09/01 06:00
CRDT- 2017/10/21 06:00
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2018/09/01 06:00 [medline]
PHST- 2017/10/21 06:00 [entrez]
AID - 10.1139/apnm-2017-0583 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2018 Mar;43(3):266-273. doi: 10.1139/apnm-2017-0583. 
      Epub 2017 Oct 20.