PMID- 29054069
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20180731
IS  - 1873-4162 (Electronic)
IS  - 1344-6223 (Linking)
VI  - 29
DP  - 2017 Nov
TI  - Postmortem distribution of chlorpyrifos-methyl, fenitrothion, and their 
      metabolites in body fluids and organ tissues of an intoxication case.
PG  - 44-50
LID - S1344-6223(17)30112-8 [pii]
LID - 10.1016/j.legalmed.2017.10.002 [doi]
AB  - We herein report a fatal intoxication case caused by the ingestion of the 
      insecticides chlorpyrifos-methyl (CPFM) and fenitrothion (MEP). A 70-year-old man 
      was found dead in his house and a cup containing a small amount of agricultural 
      chemicals was on the table near his body. External and internal examinations 
      revealed no injuries. In a gas chromatography-mass spectrometry (GC-MS) screening 
      test, CPFM, MEP, and their metabolites, 3,5,6-trichloro-2-pyridinol (TCPY) and 
      3-methyl-4-nitrophenol (3MNP), respectively, were qualitatively detected in his 
      stomach contents. The concentrations (microg/g) of CPFM, TCPY, MEP, and 3MNP in the 
      extracts of each body fluid and organ tissue were assessed by GC-MS and were as 
      follows: 27.8, 56.2, 17.2, and 2.82 (heart blood); 6.60, 42.9, 1.80, and 2.59 
      (peripheral blood); 0.0821, 45.9, 2,09, and 102 (urine); 21.4, 26.6, 76.2, and 
      3.83 (brain (frontal portion)); 16.1, 101, 9.67, and 1.26 (liver); 7.45, 101, 
      21.4, and 26.1 (right kidney); and 73,500, 9750, 232,000, and 1880 (stomach 
      contents), respectively. Based on these results and autopsy findings, the cause 
      of death was acute fatal intoxication by CPFM and MEP.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Takayasu, Tatsunori
AU  - Takayasu T
AD  - Forensic Toxicology Unit, Department of Forensic Medicine and Pathology, Graduate 
      School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan. 
      Electronic address: takayasu@staff.kanazawa-u.ac.jp.
FAU - Yamamoto, Hiroki
AU  - Yamamoto H
AD  - Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, 
      Japan.
FAU - Ishida, Yuko
AU  - Ishida Y
AD  - Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, 
      Japan.
FAU - Nosaka, Mizuho
AU  - Nosaka M
AD  - Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, 
      Japan.
FAU - Kawaguchi, Mariko
AU  - Kawaguchi M
AD  - Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, 
      Japan.
FAU - Kuninaka, Yumi
AU  - Kuninaka Y
AD  - Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, 
      Japan.
FAU - Kimura, Akihiko
AU  - Kimura A
AD  - Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, 
      Japan.
FAU - Kondo, Toshikazu
AU  - Kondo T
AD  - Department of Forensic Medicine, Wakayama Medical University, Wakayama 641-8509, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20171004
PL  - Ireland
TA  - Leg Med (Tokyo)
JT  - Legal medicine (Tokyo, Japan)
JID - 100889186
RN  - 0 (Insecticides)
RN  - JCS58I644W (Chlorpyrifos)
RN  - O49S38267J (chlorpyrifos-methyl)
RN  - W8M4X3Y7ZY (Fenitrothion)
SB  - IM
MH  - Aged
MH  - Autopsy/methods
MH  - Body Fluids/*chemistry
MH  - Chlorpyrifos/adverse effects/*analogs & derivatives/analysis/metabolism
MH  - Fenitrothion/adverse effects/*analysis/*metabolism
MH  - Gas Chromatography-Mass Spectrometry
MH  - Gastrointestinal Contents/chemistry
MH  - Humans
MH  - Insecticides/adverse effects/*analysis/*metabolism
MH  - Male
OTO - NOTNLM
OT  - 3,5,6-Trichloro-2-pyridinol
OT  - 3-Methyl-4-nitrophenol
OT  - Chlorpyrifos-methyl
OT  - Fenitrothion
OT  - Postmortem distribution
EDAT- 2017/10/21 06:00
MHDA- 2018/08/01 06:00
CRDT- 2017/10/21 06:00
PHST- 2017/03/27 00:00 [received]
PHST- 2017/09/22 00:00 [revised]
PHST- 2017/10/03 00:00 [accepted]
PHST- 2017/10/21 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2017/10/21 06:00 [entrez]
AID - S1344-6223(17)30112-8 [pii]
AID - 10.1016/j.legalmed.2017.10.002 [doi]
PST - ppublish
SO  - Leg Med (Tokyo). 2017 Nov;29:44-50. doi: 10.1016/j.legalmed.2017.10.002. Epub 
      2017 Oct 4.