PMID- 29054819
OWN - NLM
STAT- MEDLINE
DCOM- 20180710
LR  - 20181201
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 163
DP  - 2017 Dec
TI  - High ambient temperature facilitates the acquisition of 
      3,4-methylenedioxymethamphetamine (MDMA) self-administration.
PG  - 38-49
LID - S0091-3057(17)30470-7 [pii]
LID - 10.1016/j.pbb.2017.10.008 [doi]
AB  - RATIONALE: MDMA alters body temperature in rats with a direction that depends on 
      the ambient temperature (T(A)). The thermoregulatory effects of MDMA and T(A) may 
      affect intravenous self-administration (IVSA) of MDMA but limited prior reports 
      conflict. OBJECTIVE: To determine how body temperature responses under high and 
      low T(A) influence MDMA IVSA. METHODS: Male Sprague-Dawley rats were trained to 
      IVSA MDMA (1.0mg/kg/infusion; 2-h sessions; FR5 schedule of reinforcement) under 
      T(A) 20 degrees C or 30 degrees C. Radiotelemetry transmitters recorded body temperature and 
      activity during IVSA. RESULTS: MDMA intake increased under both T(A) during 
      acquisition, but to a greater extent in the 30 degrees C group. The magnitude of 
      hypothermia was initially equivalent between groups but diminished over training 
      in the 30 degrees C group. Within-session activity was initially lower in the 30 degrees C group, 
      but by the end of acquisition and maintenance, activity was similar for both 
      groups. When T(A) conditions were swapped, the hot-trained group increased MDMA 
      IVSA under 20 degrees C T(A) and a modest decrease in drug intake was observed in the 
      cold-trained group under 30 degrees C T(A). Subsequent non-contingent MDMA (1.0-5.0mg/kg, 
      i.v.) found that rats with higher MDMA IVSA rates showed blunted hypothermia 
      compared with rats with lower IVSA levels; however, within-session activity did 
      not differ by group. High T(A) increased intracranial self-stimulation thresholds 
      in a different group of rats and MDMA reduced thresholds below baseline at low, 
      but not high, T(A). CONCLUSIONS: High T(A) appears to enhance acquisition of MDMA 
      IVSA through an aversive effect and not via thermoregulatory motivation.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Aarde, Shawn M
AU  - Aarde SM
AD  - Department of Neuroscience, The Scripps Research Institute; La Jolla, CA, USA.
FAU - Huang, Pai-Kai
AU  - Huang PK
AD  - Department of Neuroscience, The Scripps Research Institute; La Jolla, CA, USA.
FAU - Taffe, Michael A
AU  - Taffe MA
AD  - Department of Neuroscience, The Scripps Research Institute; La Jolla, CA, USA. 
      Electronic address: mtaffe@scripps.edu.
LA  - eng
GR  - R01 DA024105/DA/NIDA NIH HHS/United States
GR  - R01 DA042211/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20171017
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Hallucinogens/*administration & dosage
MH  - *Hot Temperature
MH  - Locomotion/drug effects
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
PMC - PMC5688002
MID - NIHMS916214
OTO - NOTNLM
OT  - Ecstasy
OT  - Reward
OT  - Thermoregulation
EDAT- 2017/10/22 06:00
MHDA- 2018/07/11 06:00
PMCR- 2018/12/01
CRDT- 2017/10/22 06:00
PHST- 2017/08/01 00:00 [received]
PHST- 2017/09/19 00:00 [revised]
PHST- 2017/10/16 00:00 [accepted]
PHST- 2017/10/22 06:00 [pubmed]
PHST- 2018/07/11 06:00 [medline]
PHST- 2017/10/22 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - S0091-3057(17)30470-7 [pii]
AID - 10.1016/j.pbb.2017.10.008 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2017 Dec;163:38-49. doi: 10.1016/j.pbb.2017.10.008. Epub 
      2017 Oct 17.