PMID- 29055190
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20180723
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 53
DP  - 2017 Dec
TI  - Pinocembrin attenuates allergic airway inflammation via inhibition of NF-kappaB 
      pathway in mice.
PG  - 90-95
LID - S1567-5769(17)30374-0 [pii]
LID - 10.1016/j.intimp.2017.10.005 [doi]
AB  - Pinocembrin, one of the primary flavonoids in propolis, possesses many biological 
      activities, including anti-inflammation, anti-oxidation and immunoregulation. 
      This study aimed to evaluate whether pinocembrin could attenuate ovalbumin 
      (OVA)-induced allergic airway inflammation in mice and to explore the possible 
      mechanism. BALB/c mice sensitized and challenged with OVA were administered 
      intraperitoneally with pinocembrin. Airway inflammation and airway 
      hyperresponsiveness were examined. T-helper type (Th) 2 cytokines in 
      bronchoalveolar lavage fluid (BALF) and OVA-specific immunoglobulin E (IgE) in 
      serum were determined. The activation of nuclear factor kappa B (NF-kappaB) p65 were 
      also measured. Our results showed that pinocembrin resulted in significant 
      inhibition of pathophysiological signs of allergic asthma, including increased 
      pulmonary eosinophilia infiltration, mucus hypersecretion and airway 
      hyperresponsiveness (AHR). Treatment with pinocembrin significantly reduced Th2 
      cytokines interleukin (IL)-4, IL-5 and IL-13 in BALF, and OVA-specific IgE in 
      serum. Moreover, pinocembrin treatment suppressed phosphorylation of 
      inhibitor-kappaBalpha (IkappaBalpha) and NF-kappaB subunit p65 activation in lung tissue of 
      OVA-sensitized mice. These data suggest that pinocembrin may inhibit allergic 
      airway inflammation, and providing potential benefits in the treatment of 
      inflammatory disease.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Gu, Xiaoyan
AU  - Gu X
AD  - Department of Rehabilitation, The Affiliated Jiangning Hospital of Nanjing 
      Medical University, 168 drum Hill Road, Dongshan Street, Jiangning District, 
      Nanjing 211100, PR China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Respiratory Medicine, Changzhou No. 2 People's Hospital Affiliated 
      to Nanjing Medical University, Changzhou 213003, PR China.
FAU - Du, Qiang
AU  - Du Q
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital, Nanjing 
      Medical University, 121 Jiangjiayuan Road, Nanjing 210011, PR China. Electronic 
      address: jingshuyue@163.com.
FAU - Shen, Hong
AU  - Shen H
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital, Nanjing 
      Medical University, 121 Jiangjiayuan Road, Nanjing 210011, PR China.
FAU - Zhu, Zhenghua
AU  - Zhu Z
AD  - Department of Respiratory Medicine, The Second Affiliated Hospital, Nanjing 
      Medical University, 121 Jiangjiayuan Road, Nanjing 210011, PR China.
LA  - eng
PT  - Journal Article
DEP - 20171018
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Flavanones)
RN  - 0 (NF-kappa B)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8T7C8CH791 (pinocembrin)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Asthma/*drug therapy
MH  - Bronchoalveolar Lavage Fluid/immunology
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Flavanones/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Inflammation/*drug therapy
MH  - Lung/drug effects/*pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/metabolism
MH  - Ovalbumin/immunology
MH  - Signal Transduction
MH  - Th2 Cells/*immunology
OTO - NOTNLM
OT  - Airway inflammation
OT  - Asthma
OT  - Nuclear factor-kappaB
OT  - Pinocembrin
EDAT- 2017/10/22 06:00
MHDA- 2018/07/24 06:00
CRDT- 2017/10/22 06:00
PHST- 2017/05/22 00:00 [received]
PHST- 2017/09/18 00:00 [revised]
PHST- 2017/10/04 00:00 [accepted]
PHST- 2017/10/22 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/10/22 06:00 [entrez]
AID - S1567-5769(17)30374-0 [pii]
AID - 10.1016/j.intimp.2017.10.005 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2017 Dec;53:90-95. doi: 10.1016/j.intimp.2017.10.005. Epub 
      2017 Oct 18.