PMID- 29055444
OWN - NLM
STAT- MEDLINE
DCOM- 20180607
LR  - 20180607
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 17
DP  - 2017 Oct
TI  - Progressive multifocal leukoencephalopathy - immune reconstitution inflammatory 
      syndrome (PML-IRIS) in liver transplant recipient.
PG  - 135-137
LID - S2211-0348(17)30179-7 [pii]
LID - 10.1016/j.msard.2017.07.018 [doi]
AB  - 65-year-old liver transplant recipient presented with progressive neurologic 
      dysfunction. CSF analysis revealed high JC virus load and MRI findings suggested 
      the diagnosis of progressive multifocal leukoencephalopathy (PML). Cidofovir and 
      mirtazapine were initiated and patient's regular immunosuppressants were reduced. 
      Subsequently patient developed left sided hemiplegia, drowsiness and severe 
      neglect syndrome. MRI revealed enlargement of PML lesions with contrast 
      enhancement and worsening of oedema, consistent with immune reconstitution 
      inflammatory syndrome (IRIS). Steroids were initiated and 3 weeks later patient 
      showed moderate neurologic improvement. PML-IRIS after solid organ 
      transplantation is rarely detected and to the best of our knowledge, this is the 
      first reported case of PML-IRIS in a liver transplant recipient.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Avsenik, J
AU  - Avsenik J
AD  - Clinical Radiology Institute, University Medical Centre Ljubljana, Zaloska cesta 
      7, 1000 Ljubljana, Slovenia. Electronic address: jernej.avsenik@gmail.com.
FAU - Horvat Ledinek, A
AU  - Horvat Ledinek A
AD  - Department of Neurology, University Medical Centre Ljubljana, Zaloska cesta 2, 
      1000 Ljubljana, Slovenia.
FAU - Surlan Popovic, K
AU  - Surlan Popovic K
AD  - Clinical Radiology Institute, University Medical Centre Ljubljana, Zaloska cesta 
      7, 1000 Ljubljana, Slovenia.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170719
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Aged
MH  - Humans
MH  - Immune Reconstitution
MH  - Immune Reconstitution Inflammatory Syndrome/*etiology
MH  - Immunosuppressive Agents/*adverse effects/therapeutic use
MH  - JC Virus
MH  - Leukoencephalopathy, Progressive Multifocal/diagnostic 
      imaging/*etiology/physiopathology
MH  - *Liver Transplantation
MH  - Male
MH  - *Postoperative Complications/diagnostic imaging/physiopathology
OTO - NOTNLM
OT  - IRIS
OT  - Liver transplantation
OT  - Neglect syndrome
OT  - PML
OT  - PML-IRIS
EDAT- 2017/10/23 06:00
MHDA- 2018/06/08 06:00
CRDT- 2017/10/23 06:00
PHST- 2017/03/13 00:00 [received]
PHST- 2017/06/27 00:00 [revised]
PHST- 2017/07/18 00:00 [accepted]
PHST- 2017/10/23 06:00 [entrez]
PHST- 2017/10/23 06:00 [pubmed]
PHST- 2018/06/08 06:00 [medline]
AID - S2211-0348(17)30179-7 [pii]
AID - 10.1016/j.msard.2017.07.018 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2017 Oct;17:135-137. doi: 10.1016/j.msard.2017.07.018. 
      Epub 2017 Jul 19.