PMID- 2905548
OWN - NLM
STAT- MEDLINE
DCOM- 19890216
LR  - 20191029
IS  - 0270-3211 (Print)
IS  - 0270-3211 (Linking)
VI  - 8
IP  - 6
DP  - 1988
TI  - Relationship of periventricular overgrowth to hydrocephalus in brains of fetal 
      rats exposed to benomyl.
PG  - 377-91
AB  - Benomyl, a benzimidazole fungicide, was administered by gavage to pregnant 
      Sprague-Dawley rats in a daily dose of 62.5 mg/kg of maternal body weight 
      beginning at gestational day (GD) 7. Fetuses examined histologically at GD16 or 
      GD20 revealed a high incidence of craniocerebral anomalies--82.6% of those 
      examined at GD16 and 100% of those examined at GD20. Hydrocephalus occurred in 
      65.2% of fetuses examined at GD16 and in 58.8% at GD20 but was more severe in the 
      GD20 fetuses. A second common anomaly, termed periventricular "overgrowth" (PVO), 
      consisted of subependymal cell masses that in some fetuses obliterated normal 
      subcortical structures. PVO occurred in 34.8% of fetuses examined at GD16 and 
      76.5% at GD20. The size of the subependymal masses and the regions involved were 
      considerably greater in the GD20 than the GD16 fetuses. Less common anomalies in 
      the GD20 fetuses were periventricular necrosis (41.2%), a single fetus with 
      exencephaly and another with porencephaly. In the majority of malformed fetuses, 
      the severity of hydrocephalus did not parallel the severity of PVO around the 
      lateral and third ventricles. PVO involved tissues surrounding the cerebral 
      aqueduct in 17.4% of GD16 fetuses and 38.2% of GD20 fetuses. This "overgrowth" 
      distorted the cerebral aqueduct in a large number of fetuses with 
      ventriculomegaly, and at GD20 moderate and severe ventriculomegaly was in every 
      instance associated with a narrow or completely occluded cerebral aqueduct. These 
      relationships suggest that PVO in the midbrain may play a role in the production 
      of aqueductal stenosis and hydrocephalus in this experimental model.
FAU - Ellis, W G
AU  - Ellis WG
AD  - Department of Pathology, University of California, Davis 95616.
FAU - De Roos, F
AU  - De Roos F
FAU - Kavlock, R J
AU  - Kavlock RJ
FAU - Zeman, F J
AU  - Zeman FJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teratog Carcinog Mutagen
JT  - Teratogenesis, carcinogenesis, and mutagenesis
JID - 8100917
RN  - 0 (Carbamates)
RN  - TLW21058F5 (Benomyl)
SB  - IM
MH  - Abnormalities, Drug-Induced/*pathology
MH  - Animals
MH  - Benomyl/*toxicity
MH  - Carbamates/*toxicity
MH  - Cerebral Ventricles/*abnormalities/embryology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gestational Age
MH  - Hydrocephalus/*chemically induced
MH  - Pregnancy
MH  - Rats
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1002/tcm.1770080607 [doi]
PST - ppublish
SO  - Teratog Carcinog Mutagen. 1988;8(6):377-91. doi: 10.1002/tcm.1770080607.