PMID- 29055725
OWN - NLM
STAT- MEDLINE
DCOM- 20180724
LR  - 20240213
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 662
DP  - 2018 Jan 1
TI  - Evaluation of prolonged administration of isoflurane on cerebral blood flow and 
      default mode network in macaque monkeys anesthetized with different maintenance 
      doses.
PG  - 402-408
LID - S0304-3940(17)30860-1 [pii]
LID - 10.1016/j.neulet.2017.10.034 [doi]
AB  - OBJECT: Isoflurane is a commonly used volatile anesthetic agent in clinical 
      anesthesia and biomedical research. Prior study suggested the cerebral blood flow 
      (CBF) and default mode network (DMN) could be changed after prolonged 
      administration of isoflurane. The normal maintenance doses of isoflurane may vary 
      from light ( approximately 0.75%) to deep ( approximately 1.5 or 2%) anesthesia. However, it is not clear how 
      the duration effects are affected by the altered doses. The present study is 
      aimed to examine if the duration effects are affected when isoflurane 
      concentration is altered within normal maintenance doses. MATERIALS AND METHODS: 
      Adult rhesus monkeys (n=5, 8-12 years old, 8-10kg) were anesthetized and 
      maintained at isoflurane levels 0.89+/-0.03%, 1.05+/-0.12%, or 1.19+/-0.08%. CBF and 
      DMN of monkeys were examined using arterial spin-labeling perfusion and resting 
      state functional MRI techniques. RESULTS: the functional connectivity (FC) in the 
      dominant DMN (posterior cingulate cortex (PCC) to anterior cingulated cortex 
      (ACC) or media prefrontal cortex (MPFC)) decreased substantially and similarly 
      during 4-h administration of isoflurane at any given maintenance dosage. CBF 
      changes varied with isoflurane dosage. At the low dose ( approximately 0.89%), CBF decreased in 
      most brain regions. In contrast, no obvious changes was seen in those regions 
      (except for the subcortex) when higher doses of isoflurane were applied. 
      CONCLUSION: FC in DMN was reduced substantially during prolonged administration 
      of isoflurane. The FC reduction was not varying significantly with maintenance 
      doses of isoflurane but the duration effect on CBF was dose-dependent. Such 
      duration effects of isoflurane administration on DMN and CBF should be considered 
      in the interpretation of the outcome in related neuroimaging studies of 
      anesthetized subjects.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Li, Chun-Xia
AU  - Li CX
AD  - Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, 
      Atlanta, GA 30329, United States.
FAU - Zhang, Xiaodong
AU  - Zhang X
AD  - Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, 
      Atlanta, GA 30329, United States; Division of Neuropharmacology and Neurologic 
      Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, 
      30329, United States. Electronic address: xzhang8@emory.edu.
LA  - eng
GR  - P51 OD011132/OD/NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20171018
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Anesthetics, Inhalation)
RN  - CYS9AKD70P (Isoflurane)
SB  - IM
MH  - Anesthetics, Inhalation/*administration & dosage
MH  - Animals
MH  - Brain/*drug effects
MH  - Cerebrovascular Circulation/*drug effects
MH  - Female
MH  - Isoflurane/*administration & dosage
MH  - Macaca mulatta
PMC - PMC5722273
MID - NIHMS919129
OTO - NOTNLM
OT  - Anesthesia
OT  - CBF
OT  - Default mode network (DMN)
OT  - Dosage effect
OT  - Functional MRI
OT  - Non-human primate
OT  - Pseudo continuous arterial-spin-labeling (pCASL)
COIS- Conflict of interest statement The authors have no conflict of interest to claim.
EDAT- 2017/10/23 06:00
MHDA- 2018/07/25 06:00
PMCR- 2019/01/01
CRDT- 2017/10/23 06:00
PHST- 2017/05/21 00:00 [received]
PHST- 2017/09/27 00:00 [revised]
PHST- 2017/10/17 00:00 [accepted]
PHST- 2017/10/23 06:00 [pubmed]
PHST- 2018/07/25 06:00 [medline]
PHST- 2017/10/23 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - S0304-3940(17)30860-1 [pii]
AID - 10.1016/j.neulet.2017.10.034 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Jan 1;662:402-408. doi: 10.1016/j.neulet.2017.10.034. Epub 
      2017 Oct 18.