PMID- 29055810
OWN - NLM
STAT- MEDLINE
DCOM- 20180731
LR  - 20180801
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 74
DP  - 2017 Dec
TI  - Prenatal caffeine ingestion increases susceptibility to pulmonary inflammation in 
      adult female rat offspring.
PG  - 212-218
LID - S0890-6238(17)30284-8 [pii]
LID - 10.1016/j.reprotox.2017.10.006 [doi]
AB  - This study aimed to investigate the association between prenatal caffeine 
      ingestion (PCI) and risk of postnatal pulmonary inflammation. Pregnant Wistar 
      rats were administered 60mg/kg/d caffeine intragastrically from gestational day 
      (GD) 7 to GD 20. The results showed that PCI obviously increased intrauterine 
      growth retardation rate to 39.2% and suppressed weight growth of the offspring. 
      PCI also enhanced the expression of transforming growth factor beta, alpha-smooth muscle 
      actin, interleukin (IL)-1beta, and IL-8 in lungs and caused pulmonary interstitial 
      thickening in the offspring. Further, with lipopolysaccharide stimulation on 
      postnatal day 77, PCI offspring showed more serious inflammatory infiltration, 
      higher injury scores, and higher levels of IL-6 and tumor necrosis factor-alpha in 
      lungs than those of the control. Our findings showed, for the first time, that 
      PCI is a certainly threat to postnatal pulmonary inflammation. The potential 
      mechanism is that PCI alter the expression of pulmonary interstitial 
      thickening-associated genes in the offspring.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Liu, Han-Xiao
AU  - Liu HX
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Hou, Li-Fang
AU  - Hou LF
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Chen, Ting
AU  - Chen T
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Qu, Wen
AU  - Qu W
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Liu, Sha
AU  - Liu S
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Yan, Hui-Yi
AU  - Yan HY
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Wen, Xiao
AU  - Wen X
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China.
FAU - Ping, Jie
AU  - Ping J
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China. Electronic address: pingjie@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171018
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Cytokines)
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Animals
MH  - Caffeine/*toxicity
MH  - Cytokines/genetics/immunology
MH  - Female
MH  - Fetal Growth Retardation/chemically induced
MH  - Inflammation/*chemically induced/genetics/immunology/pathology
MH  - Lung/*drug effects/immunology/pathology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats, Wistar
OTO - NOTNLM
OT  - IL-6
OT  - IUGR
OT  - Prenatal caffeine ingestion
OT  - Pulmonary inflammation
OT  - Pulmonary interstitial thickness
OT  - TNF-alpha
EDAT- 2017/10/23 06:00
MHDA- 2018/08/01 06:00
CRDT- 2017/10/23 06:00
PHST- 2017/05/30 00:00 [received]
PHST- 2017/09/19 00:00 [revised]
PHST- 2017/10/17 00:00 [accepted]
PHST- 2017/10/23 06:00 [pubmed]
PHST- 2018/08/01 06:00 [medline]
PHST- 2017/10/23 06:00 [entrez]
AID - S0890-6238(17)30284-8 [pii]
AID - 10.1016/j.reprotox.2017.10.006 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Dec;74:212-218. doi: 10.1016/j.reprotox.2017.10.006. Epub 
      2017 Oct 18.