PMID- 29057125 OWN - NLM STAT- MEDLINE DCOM- 20180622 LR - 20181202 IS - 1687-5443 (Electronic) IS - 2090-5904 (Print) IS - 1687-5443 (Linking) VI - 2017 DP - 2017 TI - The Effect of Aerobic Exercise on Brain-Derived Neurotrophic Factor in People with Neurological Disorders: A Systematic Review and Meta-Analysis. PG - 4716197 LID - 10.1155/2017/4716197 [doi] LID - 4716197 AB - OBJECTIVE: To determine the effect of aerobic exercise on brain-derived neurotrophic factor (BDNF) levels in people with neurological disorders. DATA SOURCES: Six electronic databases (CINAHL, PubMed, Cochrane, PsycINFO, SportDiscus, and Web of Science) were searched until the end of December 2016. STUDY SELECTION: Experimental or observational studies of people with neurological disorders who undertook an exercise intervention with BDNF as an outcome measure. The search strategy yielded 984 articles. DATA EXTRACTION: Study data were independently extracted from each article. Methodological quality of studies was assessed using the Physiotherapy Evidence Database (PEDro) scale. A meta-analysis was planned based on the assessment of predetermined criteria. DATA SYNTHESIS: Eleven articles were included. Studies employed either a program of aerobic exercise, a single bout of aerobic exercise, or both. A meta-analysis of studies comparing a program of aerobic exercise against usual care/nil therapy showed a large effect (SMD: 0.84, 95% CI 0.47-1.20, p < 0.001) in favour of aerobic exercise to increase levels of BDNF. Findings for a single bout of aerobic exercise were mixed. Quality of studies was low (PEDro average score 4.3/10). CONCLUSIONS: A program of aerobic exercise may contribute to increased levels of BDNF in neurological populations. FAU - Mackay, Christopher P AU - Mackay CP AUID- ORCID: 0000-0003-4986-5913 AD - Faculty of Health and Behavioural Sciences, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. FAU - Kuys, Suzanne S AU - Kuys SS AUID- ORCID: 0000-0002-6263-4223 AD - Faculty of Health Sciences, School of Physiotherapy, Australian Catholic University, Brisbane, Australia. FAU - Brauer, Sandra G AU - Brauer SG AD - Faculty of Health and Behavioural Sciences, School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Australia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20170919 PL - United States TA - Neural Plast JT - Neural plasticity JID - 100883417 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Brain/*metabolism MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Exercise/*physiology MH - *Exercise Therapy MH - Humans MH - Multiple Sclerosis/metabolism/*therapy MH - Parkinson Disease/metabolism/*therapy MH - Quality of Life MH - Stroke/*therapy PMC - PMC5625797 EDAT- 2017/10/24 06:00 MHDA- 2018/06/23 06:00 PMCR- 2017/09/19 CRDT- 2017/10/24 06:00 PHST- 2017/05/09 00:00 [received] PHST- 2017/08/09 00:00 [accepted] PHST- 2017/10/24 06:00 [entrez] PHST- 2017/10/24 06:00 [pubmed] PHST- 2018/06/23 06:00 [medline] PHST- 2017/09/19 00:00 [pmc-release] AID - 10.1155/2017/4716197 [doi] PST - ppublish SO - Neural Plast. 2017;2017:4716197. doi: 10.1155/2017/4716197. Epub 2017 Sep 19.