PMID- 29057245
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2306-9759 (Print)
IS  - 2313-0792 (Electronic)
IS  - 2306-9759 (Linking)
VI  - 4
DP  - 2017
TI  - A case report of congenital glycogen storage liver cirrhosis treated with bone 
      marrow derived stem cells.
PG  - 73
LID - 10.21037/sci.2017.07.04 [doi]
LID - 73
AB  - Liver cirrhosis represents a state of end-stage failure that is usually fatal. 
      The condition results in liver dysfunction, recurrent ascites, encephalopathy, 
      renal failure, splenomegaly, bleeding, and a poor quality of life in general. 
      With the current severe shortage of donated organs, the only available treatment 
      in the developing countries remains palliative care. We report a case of 
      congenital metabolic liver cirrhosis due to glycogen storage disease diagnosed at 
      age eight. The patient, a male, received bone marrow derived mononuclear cells 
      (BMMC) at age 16 and again at age 17 with significant improvement of his 
      biochemical liver function tests, ascites build-up, asthenia, splenomegaly and 
      quality of life. Furthermore, liver biopsies showed clear reduction of the 
      inflammation and fibrosis from Ishak score dropped from 3 to 1 paralleling the 
      symptomatic improvement of the patient.
FAU - Wehbe, Terek W
AU  - Wehbe TW
AD  - Department of Hematology, The Notre Dame University Hospital, Jounieh, Lebanon.
FAU - Abi Chahine, Nassim H
AU  - Abi Chahine NH
AD  - Department of Neurosurgery, The Lebanese-Canadian Hospital, Beirut, Lebanon.
FAU - Annous, Abdul-Rahman A
AU  - Annous AA
AD  - Hanan Lebanese-French Laboratory for Pathology, University of Balamand and Open 
      Arab University, Balamand Al Kurah, Lebanon.
FAU - Ferri, Mohammad A
AU  - Ferri MA
AD  - Al-Salam Hospital, Department of Gastroenterology, Tripoli, Lebanon.
FAU - Boulous, Robert C
AU  - Boulous RC
AD  - Department of Pathology, The Notre Dame University Hospital, Beirut, Lebanon.
FAU - El-Mestrah, Majid F
AU  - El-Mestrah MF
AD  - The Lebanese University, Beirut, Lebanon.
LA  - eng
PT  - Case Reports
DEP - 20170907
PL  - China
TA  - Stem Cell Investig
JT  - Stem cell investigation
JID - 101672113
PMC - PMC5638994
OTO - NOTNLM
OT  - Mononuclear stem cells
OT  - bone marrow cells
OT  - liver cirrhosis
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2017/10/24 06:00
MHDA- 2017/10/24 06:01
PMCR- 2017/09/07
CRDT- 2017/10/24 06:00
PHST- 2017/05/01 00:00 [received]
PHST- 2017/07/13 00:00 [accepted]
PHST- 2017/10/24 06:00 [entrez]
PHST- 2017/10/24 06:00 [pubmed]
PHST- 2017/10/24 06:01 [medline]
PHST- 2017/09/07 00:00 [pmc-release]
AID - sci-04-2017.07.04 [pii]
AID - 10.21037/sci.2017.07.04 [doi]
PST - epublish
SO  - Stem Cell Investig. 2017 Sep 7;4:73. doi: 10.21037/sci.2017.07.04. eCollection 
      2017.