PMID- 29057536
OWN - NLM
STAT- MEDLINE
DCOM- 20190221
LR  - 20220408
IS  - 1097-4652 (Electronic)
IS  - 0021-9541 (Linking)
VI  - 233
IP  - 5
DP  - 2018 May
TI  - The combination of plasma fibrinogen and neutrophil lymphocyte ratio (F-NLR) is a 
      predictive factor in patients with resectable non small cell lung cancer.
PG  - 4216-4224
LID - 10.1002/jcp.26239 [doi]
AB  - The prognostic value of inflammation indexes in non small cell lung cancer 
      (NSCLC) was not established. Therefore, we assessed the clinical applicability of 
      the F-NLR score, which is based on fibrinogen (F) and the neutrophil-lymphocyte 
      ratio (NLR), and the glasgow prognostic score (GPS) to predict the prognoses of 
      NSCLC patients. We retrospectively identified 515 patients with stage I/II/IIIA 
      who underwent surgery at our institution, and evaluated their preoperative serum 
      levels of CRP, albumin, fibrinogen, neutrophil count, and the lymphocyte count. 
      The cut-off values of the fibrinogen level and NLR were determined with receiver 
      operating characteristic (ROC) curve. GPS was classified into three groups as 
      previously described. The disease free survival (DFS) and overall survival (OS) 
      were calculated by the Kaplan-Meier method. Categorical variables were compared 
      using the chi(2) test. Survival curves were estimated using the Kaplan-Meier 
      method, and the Cox proportional hazard model was used to assess the prognostic 
      factors. The F-NLR was significantly associated with sex (p = 0.000), smoking 
      history (p = 0.014), lesion type (p = 0.000), histologic type (p = 0.000), T 
      stage (p = 0.000), venous invasion (p = 0.000), lymphatic invasion (p = 0.000), 
      and TNM stage (p = 0.000). The 5-year DFS rates in F-NLR groups 0, 1, and 2 were 
      46.7%, 36.4%, 30.1%, respectively (p = 0.000), and the 5-year overall survival 
      (OS) rates in the above three groups were 52.0%, 39.8%, 32.1%, respectively 
      (p = 0.000). Multivariate analysis showed that venous invasion (p = 0.036), lymph 
      node metastasis (p = 0.000), and F-NLR (p = 0.034) were independent prognostic 
      factors for DFS. Age (p = 0.015), venous invasion (p = 0.024), lymph node 
      metastasis (p = 0.000), and F-NLR (p = 0.019) were independent prognostic factors 
      for OS. Thus, F-NLR was the independent prognostic factor for both the DFS and 
      OS. And patients with a high-risk preoperative F-NLR group may benefit from 
      adjuvant therapy by subgroup analysis. Our results demonstrated that F-NLR, a 
      novel inflammation-based grading system, as well as the GPS, appeared to have 
      value as a promising clinical predictor of the prognosis for the resectable non 
      small cell lung cancer patients.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Wang, Haiyan
AU  - Wang H
AUID- ORCID: 0000-0001-8201-7815
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou City, Hebei 
      Province, China.
FAU - Zhao, Jin
AU  - Zhao J
AD  - Department of Medical Oncology, Cangzhou Central Hospital, Cangzhou City, Hebei 
      Province, China.
FAU - Zhang, Mingyun
AU  - Zhang M
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou City, Hebei 
      Province, China.
FAU - Han, Lijie
AU  - Han L
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou City, Hebei 
      Province, China.
FAU - Wang, Ming
AU  - Wang M
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou City, Hebei 
      Province, China.
FAU - Xingde, Li
AU  - Xingde L
AD  - Department of Radiation Oncology, Cangzhou Central Hospital, Cangzhou City, Hebei 
      Province, China.
LA  - eng
PT  - Journal Article
DEP - 20171226
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Biomarkers, Tumor)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/blood
MH  - Carcinoma, Non-Small-Cell Lung/*blood/pathology
MH  - Disease-Free Survival
MH  - Female
MH  - Fibrinogen/*metabolism
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lymphatic Metastasis
MH  - Lymphocyte Count
MH  - Lymphocytes/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/*metabolism/pathology
MH  - Prognosis
OTO - NOTNLM
OT  - fibrinogen
OT  - neutrophil-lymphocyte ratio
OT  - non small cell lung cancer
OT  - prognosis
EDAT- 2017/10/24 06:00
MHDA- 2019/02/23 06:00
CRDT- 2017/10/24 06:00
PHST- 2017/08/17 00:00 [received]
PHST- 2017/10/13 00:00 [accepted]
PHST- 2017/10/24 06:00 [pubmed]
PHST- 2019/02/23 06:00 [medline]
PHST- 2017/10/24 06:00 [entrez]
AID - 10.1002/jcp.26239 [doi]
PST - ppublish
SO  - J Cell Physiol. 2018 May;233(5):4216-4224. doi: 10.1002/jcp.26239. Epub 2017 Dec 
      26.