PMID- 29058041
OWN - NLM
STAT- MEDLINE
DCOM- 20181219
LR  - 20220408
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 235
IP  - 1
DP  - 2018 Jan
TI  - Dihydromyricetin exerts a rapid antidepressant-like effect in association with 
      enhancement of BDNF expression and inhibition of neuroinflammation.
PG  - 233-244
LID - 10.1007/s00213-017-4761-z [doi]
AB  - RATIONALE: Major depressive disorder (MDD) is a highly prevalent illness that 
      affects large populations across the world, and increasing evidence suggests that 
      neuroinflammation and levels of brain-derived neurotrophic factor (BDNF) are 
      closely related to depression. Dihydromyricetin (DHM) is a kind of flavonoid 
      natural product that has been reported to display multiple pharmacological 
      effects, including anti-inflammatory and anti-oxidative properties, and these may 
      contribute to ameliorate MDD. OBJECTIVE: This study investigated the effect of 
      DHM on depression-related phenotypes in various experimental animal models. 
      METHODS: The antidepressant-like effect of DHM was validated via 
      depression-related behavioral tests in naive male C57BL/6 mice, as well as in the 
      acute lipopolysaccharide-induced mouse model of depression. The chronic 
      unpredicted mild stress (CUMS) mouse model of depression was also used to assess 
      the rapid antidepressant-like effect of DHM by tail suspension test (TST), forced 
      swimming test (FST), locomotor activity, and sucrose preference test (SPT). The 
      expression of BDNF and inflammatory factors were determined through Western 
      blotting and enzyme-linked immunosorbent assay, respectively. RESULTS: DHM 
      reduced immobility time in the TST and FST both in mice and the acute LPS-induced 
      mouse model of depression. Seven days of DHM treatment ameliorated 
      depression-related behaviors induced by CUMS, whereas similar treatment with the 
      typical antidepressant venlafaxine did not. DHM activated the ERK1/2-CREB pathway 
      and increased glycogen synthase kinase-3 beta (GSK-3beta) phosphorylation at ser-9, 
      with upregulation of BDNF expression, in both hippocampal tissues and cultured 
      hippocampal cells. CONCLUSION: The present data indicate that DHM exerts a more 
      rapid antidepressant-like effect than does a typical antidepressant, in 
      association with enhancement of BDNF expression and inhibition of 
      neuroinflammation.
FAU - Ren, Zhaoxiang
AU  - Ren Z
AD  - Jiangsu Key laboratory for Translational Research and Therapy for 
      Neuropsychiatric disorders, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, Jiangsu Province, 215123, China.
FAU - Yan, Pengju
AU  - Yan P
AD  - Jiangsu Key laboratory for Translational Research and Therapy for 
      Neuropsychiatric disorders, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, Jiangsu Province, 215123, China.
FAU - Zhu, Liushuai
AU  - Zhu L
AD  - Jiangsu Key laboratory for Translational Research and Therapy for 
      Neuropsychiatric disorders, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, Jiangsu Province, 215123, China.
FAU - Yang, Huicui
AU  - Yang H
AD  - Jiangsu Key laboratory for Translational Research and Therapy for 
      Neuropsychiatric disorders, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, Jiangsu Province, 215123, China.
FAU - Zhao, Yafei
AU  - Zhao Y
AD  - Jiangsu Key laboratory for Translational Research and Therapy for 
      Neuropsychiatric disorders, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, Jiangsu Province, 215123, China.
FAU - Kirby, Brian P
AU  - Kirby BP
AD  - School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
FAU - Waddington, John L
AU  - Waddington JL
AD  - Jiangsu Key laboratory for Translational Research and Therapy for 
      Neuropsychiatric disorders, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, Jiangsu Province, 215123, China.
AD  - Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 
      2, Ireland.
FAU - Zhen, Xuechu
AU  - Zhen X
AD  - Jiangsu Key laboratory for Translational Research and Therapy for 
      Neuropsychiatric disorders, College of Pharmaceutical Sciences, Soochow 
      University, Suzhou, Jiangsu Province, 215123, China. zhenxuechu@suda.edu.cn.
AD  - The Collaborative Innovation Center for Brain Science, Soochow University, 
      Suzhou, Jiangsu Province, 215123, China. zhenxuechu@suda.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171020
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonols)
RN  - EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
RN  - KD8QND6427 (dihydromyricetin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depressive Disorder/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Flavonols/*pharmacology
MH  - Glycogen Synthase Kinase 3 beta/metabolism
MH  - Hindlimb Suspension
MH  - Hippocampus/drug effects
MH  - Locomotion/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Stress, Psychological/drug therapy/metabolism
MH  - Swimming
OTO - NOTNLM
OT  - Antidepressant activity
OT  - Brain-derived neurotrophic factor
OT  - Dihydromyricetin
OT  - ERK1/2
OT  - Glycogen synthase kinase-3beta
EDAT- 2017/10/24 06:00
MHDA- 2018/12/20 06:00
CRDT- 2017/10/24 06:00
PHST- 2017/06/20 00:00 [received]
PHST- 2017/10/11 00:00 [accepted]
PHST- 2017/10/24 06:00 [pubmed]
PHST- 2018/12/20 06:00 [medline]
PHST- 2017/10/24 06:00 [entrez]
AID - 10.1007/s00213-017-4761-z [pii]
AID - 10.1007/s00213-017-4761-z [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2018 Jan;235(1):233-244. doi: 
      10.1007/s00213-017-4761-z. Epub 2017 Oct 20.