PMID- 29058206
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 1568-5888 (Print)
IS  - 1876-6250 (Electronic)
IS  - 1568-5888 (Linking)
VI  - 26
IP  - 1
DP  - 2018 Jan
TI  - Role of cardiovascular magnetic resonance in suspected cardiac amyloidosis: late 
      gadolinium enhancement pattern as mortality predictor.
PG  - 34-40
LID - 10.1007/s12471-017-1046-4 [doi]
AB  - BACKGROUND: Cardiac magnetic resonance (CMR) has gained a central role in the 
      diagnosis of cardiac amyloidosis (CA). While the diagnostic role of a typical 
      late gadolinium enhancement (LGE) pattern (global subendocardial enhancement 
      coupled with accelerated contrast washout) has been identified, evidence is still 
      conflicting regarding the prognostic role of such examination. METHODS AND 
      RESULTS: We retrospectively analysed all patients referring for CMR at Niguarda 
      Hospital (Milan, Italy) from January 2006 to January 2015 for suspected CA. 
      Primary outcome was all-cause mortality. We identified 42 patients and divided 
      them into 2 groups, according to the presence (Group A) or absence (Group B) of 
      a typical amyloidosis LGE pattern. At the end of the follow-up (median 37 months, 
      interquartile range 10-50 months), 31 patients (74%) had died. The hazard ratio 
      for all-cause death was 3.2 (95% confidence interval [CI] 1.5-6.4, p < 0.01) for 
      Group A versus Group B. Median survival time was 17 months (95% CI 7-42 months) 
      for Group A and 70 months (95% CI 49-94 months) for Group B (p < 0.01). 
      Multivariate analysis did not find any adjunctive predictive role for 
      biventricular volumes and ejection fraction, indexed left ventricular mass, 
      transmitral E/e' at echocardiography, age at diagnosis or serum creatinine. 
      CONCLUSION: In our population, a typical LGE pattern was significantly associated 
      with higher mortality. Moreover, patients with a typical LGE pattern showed 
      a globally worse prognosis. Our data suggest that the LGE pattern may play 
      a central role in prognostic stratification of patients with suspected CA, thus 
      prompting further diagnostic and therapeutic measures.
FAU - Baroni, M
AU  - Baroni M
AUID- ORCID: 0000-0003-3948-4914
AD  - Cardiologia 3, A. De' Gasperis Heart Center, ASST Grande Ospedale Metropolitano 
      Niguarda, Milano, Italy. bimatteo@gmail.com.
FAU - Nava, S
AU  - Nava S
AD  - Cardiologia 1, A. De' Gasperis Heart Center, ASST Grande Ospedale Metropolitano 
      Niguarda, Milano, Italy.
FAU - Quattrocchi, G
AU  - Quattrocchi G
AD  - Cardiologia 4, A. De' Gasperis Heart Center, ASST Grande Ospedale Metropolitano 
      Niguarda, Milano, Italy.
FAU - Milazzo, A
AU  - Milazzo A
AD  - Cardiologia 4, A. De' Gasperis Heart Center, ASST Grande Ospedale Metropolitano 
      Niguarda, Milano, Italy.
FAU - Giannattasio, C
AU  - Giannattasio C
AD  - Cardiologia 4, A. De' Gasperis Heart Center, ASST Grande Ospedale Metropolitano 
      Niguarda, Milano, Italy.
AD  - Health Science Department, Bicocca University, Milano, Italy.
FAU - Roghi, A
AU  - Roghi A
AD  - Cardiologia 4, A. De' Gasperis Heart Center, ASST Grande Ospedale Metropolitano 
      Niguarda, Milano, Italy.
FAU - Pedrotti, P
AU  - Pedrotti P
AD  - Cardiologia 4, A. De' Gasperis Heart Center, ASST Grande Ospedale Metropolitano 
      Niguarda, Milano, Italy.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Neth Heart J
JT  - Netherlands heart journal : monthly journal of the Netherlands Society of 
      Cardiology and the Netherlands Heart Foundation
JID - 101095458
PMC - PMC5758446
OTO - NOTNLM
OT  - Amyloidosis
OT  - Cardiac magnetic resonance
COIS- M. Baroni, S. Nava, G. Quattrocchi, A. Milazzo, C. Giannattasio, A. Roghi and 
      P. Pedrotti declare that they have no competing interests.
EDAT- 2017/10/24 06:00
MHDA- 2017/10/24 06:01
PMCR- 2017/10/20
CRDT- 2017/10/24 06:00
PHST- 2017/10/24 06:00 [pubmed]
PHST- 2017/10/24 06:01 [medline]
PHST- 2017/10/24 06:00 [entrez]
PHST- 2017/10/20 00:00 [pmc-release]
AID - 10.1007/s12471-017-1046-4 [pii]
AID - 1046 [pii]
AID - 10.1007/s12471-017-1046-4 [doi]
PST - ppublish
SO  - Neth Heart J. 2018 Jan;26(1):34-40. doi: 10.1007/s12471-017-1046-4.