PMID- 29058737
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20181217
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 9
IP  - 42
DP  - 2017 Nov 2
TI  - On-demand electrically controlled drug release from resorbable nanocomposite 
      films.
PG  - 16429-16436
LID - 10.1039/c7nr06443h [doi]
AB  - Electroresponsive materials are promising carriers for developing drug delivery 
      systems (DDSs) with excellent spatial, temporal, and dosage control over drug 
      release. Current electroresponsive systems use high voltages (2-25 V), are not 
      bioresorbable, or use materials with unknown long-term biocompatibility. We 
      report here a nanocomposite film that is resorbable, electroresponsive at low 
      voltages (<-2 V), and composed of entirely FDA-approved materials. Our DDS is 
      based on poly(methyl methacrylate-co-methacrylic acid), commercially marketed as 
      Eudragit S100 (EGT), which has pH-dependent aqueous solubility. Nanometric films 
      of drug-loaded EGT were designed, synthesized, and coated with a protective layer 
      of chitosan. We hypothesized that electric stimuli would cause local pH changes 
      on the working electrode, leading to pH-responsive dissolution of EGT with 
      concomitant drug release. Our results confirm that local pH changes impart 
      electroresponsive release behavior to the films. Furthermore, drug release scales 
      linearly with voltage, current, and time. The generalizability of the system is 
      shown through the release of several molecules of varying hydrophobicity, pK(a), 
      and size, including fluorescein (free acid and sodium salt), curcumin, meloxicam, 
      and glucagon. The ability to modulate drug release with the applied stimulus can 
      be utilized to design minimally invasive drug delivery devices based on 
      bioresorbable electronics. Such devices would allow for personalized medicine in 
      the treatment of chronic diseases.
FAU - Samanta, Devleena
AU  - Samanta D
AD  - Department of Chemistry, Stanford University, Stanford, CA 94305, USA. 
      zare@stanford.edu.
FAU - Mehrotra, Rohan
AU  - Mehrotra R
FAU - Margulis, Katy
AU  - Margulis K
FAU - Zare, Richard N
AU  - Zare RN
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - Biocompatible Materials
MH  - *Drug Delivery Systems
MH  - *Drug Liberation
MH  - *Electricity
MH  - Electronics
MH  - Hydrogen-Ion Concentration
MH  - *Nanocomposites
MH  - Solubility
EDAT- 2017/10/24 06:00
MHDA- 2018/12/18 06:00
CRDT- 2017/10/24 06:00
PHST- 2017/10/24 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2017/10/24 06:00 [entrez]
AID - 10.1039/c7nr06443h [doi]
PST - ppublish
SO  - Nanoscale. 2017 Nov 2;9(42):16429-16436. doi: 10.1039/c7nr06443h.