PMID- 29059484
OWN - NLM
STAT- MEDLINE
DCOM- 20191022
LR  - 20201216
IS  - 1540-8167 (Electronic)
IS  - 1045-3873 (Linking)
VI  - 29
IP  - 1
DP  - 2018 Jan
TI  - Imaging characteristics of papillary muscle site of origin of ventricular 
      arrhythmias in patients with mitral valve prolapse.
PG  - 146-153
LID - 10.1111/jce.13374 [doi]
AB  - BACKGROUND: Mitral valve prolapse has been associated with increased risk of 
      ventricular arrhythmias. We aimed to examine whether certain cardiac imaging 
      characteristics are associated with papillary muscle origin of ventricular 
      arrhythmias in these patients. METHODS AND RESULTS: We screened electronic 
      medical records of all patients documented to have mitral valve prolapse on 
      either transthoracic echocardiogram (TTE) or cardiac magnetic resonance imaging 
      (CMR) in our center, who also underwent an electrophysiologic study (EPS) between 
      2007 and 2016. Anterior and posterior mitral leaflet thickness and prolapsed 
      distance were measured on TTE and late gadolinium enhancement (LGE) was assessed 
      on CMR. Patients were categorized as papillary muscle positive (pap (+)) or 
      negative (pap (-)) using EPS. Eighteen patients were included in this study. Of 
      the 15 patients who underwent TTE, a significantly higher proportion of patients 
      in the pap (+) group had an anterior to posterior leaflet prolapse ratio of >0.45 
      indicating more symmetric leaflet prolapse. There were no differences in anterior 
      or posterior leaflet thickness or prolapse distance between the groups. Patients 
      in the pap (+) group were more likely to be women. Of the 7 patients who 
      underwent CMR, those who were pap (+) were more likely to have LGE in the region 
      of the papillary muscles than those who were pap (-). CONCLUSION: Female gender, 
      more symmetric bileaflet prolapse on TTE, and the presence of papillary muscle 
      LGE on CMR may be associated with papillary muscle origin of ventricular 
      arrhythmias in patients with mitral valve prolapse.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Fulton, Brian L
AU  - Fulton BL
AUID- ORCID: 0000-0003-4905-8142
AD  - Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, 
      PA, USA.
FAU - Liang, Jackson J
AU  - Liang JJ
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Enriquez, Andres
AU  - Enriquez A
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Garcia, Fermin C
AU  - Garcia FC
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Supple, Gregory E
AU  - Supple GE
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Riley, Michael P
AU  - Riley MP
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Schaller, Robert D
AU  - Schaller RD
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Dixit, Sanjay
AU  - Dixit S
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Callans, David J
AU  - Callans DJ
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Marchlinski, Francis E
AU  - Marchlinski FE
AUID- ORCID: 0000-0001-7962-9423
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
FAU - Han, Yuchi
AU  - Han Y
AUID- ORCID: 0000-0001-7582-1848
AD  - Department of Medicine, Cardiovascular Division, Hospital of the University of 
      Pennsylvania, Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
DEP - 20171117
PL  - United States
TA  - J Cardiovasc Electrophysiol
JT  - Journal of cardiovascular electrophysiology
JID - 9010756
SB  - IM
CIN - J Cardiovasc Electrophysiol. 2018 May;29(5):E6. PMID: 29485223
CIN - J Cardiovasc Electrophysiol. 2018 May;29(5):E5. PMID: 29493046
MH  - Adult
MH  - Aged
MH  - Databases, Factual
MH  - *Echocardiography
MH  - Electrocardiography
MH  - Electronic Health Records
MH  - Electrophysiologic Techniques, Cardiac
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve/*diagnostic imaging/physiopathology
MH  - Mitral Valve Prolapse/complications/*diagnostic imaging/physiopathology
MH  - Papillary Muscles/*diagnostic imaging/physiopathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sex Factors
MH  - Tachycardia, Ventricular/*diagnostic imaging/etiology/physiopathology
OTO - NOTNLM
OT  - cardiac magnetic resonance imaging
OT  - electrophysiologic study
OT  - late gadolinium enhancement
OT  - mitral valve prolapse
OT  - ventricular arrhythmia
EDAT- 2017/10/24 06:00
MHDA- 2019/10/23 06:00
CRDT- 2017/10/24 06:00
PHST- 2017/05/16 00:00 [received]
PHST- 2017/09/15 00:00 [revised]
PHST- 2017/10/02 00:00 [accepted]
PHST- 2017/10/24 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2017/10/24 06:00 [entrez]
AID - 10.1111/jce.13374 [doi]
PST - ppublish
SO  - J Cardiovasc Electrophysiol. 2018 Jan;29(1):146-153. doi: 10.1111/jce.13374. Epub 
      2017 Nov 17.